Oxidation- and thermo-responsive poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogels cross-linked via diselenides for controlled drug delivery

被引：45
作者：
Cheng, Xinfeng [1 ,2 ]
Jin, Yong [3 ,4 ]
Sun, Tongbing [1 ,2 ]
Qi, Rui [1 ,2 ]
Fan, Baozhu [1 ,2 ]
Li, Hanping [3 ,4 ]
机构：
[1] Chinese Acad Sci, Ctr Polymer Sci & Technol, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Sichuan Univ, Natl Engn Lab Clean Technol Leather Mfg, Chengdu 610065, Peoples R China
[4] Sichuan Univ, Key Lab Leather Chem & Engn, Minist Educ, Chengdu 610065, Peoples R China
来源：
RSC ADVANCES | 2015年 / 5卷 / 06期
基金：
中国国家自然科学基金;
关键词：
BIOMEDICAL APPLICATIONS; RESPONSIVE POLYMERS; N-ISOPROPYLACRYLAMIDE; DEGRADABLE HYDROGELS; SENSITIVE HYDROGELS; SINGLE DISELENIDE; PHASE-TRANSITION; ACID) HYDROGELS; PH; RELEASE;
D O I：
10.1039/c4ra13500h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel diselenide crosslinked poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogel was successfully synthesized and characterized. The resultant hydrogel showed a swelling-shrinkage behavior as a function of external temperature because of the unique hydrophilic-hydrophobic transition of poly(N-isopropylacrylamide) (PNIPAM) segments. In addition to the temperature-dependent response, the oxidation-induced gel-to-sol transition of the hydrogel was also observed. The salicylic acid (SA) loaded hydrogels were prepared in order to investigate their stimuli-responsive release behaviors. The cumulative release profile of the SA-loaded hydrogels showed a thermo-induced slow sustained drug release and an oxidation-induced quick burst release, exhibiting temperature/oxidation dual-stimuli-responsive drug release. This novel type of hydrogels may hold great promise for controlled drug delivery systems.
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页码：4162 / 4170
页数：9
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