Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan

被引：42
作者：
Huang, TS
Lee, SSJ
Tu, HZ
Huang, WK
Chen, YS
Huang, CK
Wann, SR
Lin, HH
Liu, YC
机构：
[1] Kaohsiung Vet Gen Hosp, Sect Microbiol & Infect Dis, Kaohsiung, Taiwan
[2] Foo Yin Inst Technol, Dept Med Technol, Taipei, Taiwan
[3] Natl Yang Ming Med Coll, Taipei 11221, Taiwan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 11期
关键词：
D O I：
10.1128/AAC.47.11.3672-3673.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.
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页码：3672 / 3673
页数：2
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