The importance of being a pDC in antiviral immunity: the IFN mission versus Ag presentation?

被引:30
作者
Haeryfar, SMM
机构
[1] NIAID, Cellular Biol Sect, Viral Dis Lab, NIH, Bethesda, MD 20892 USA
[2] NIAID, Viral Immunol Sect, Viral Dis Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/j.it.2005.04.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Plasmacytoid pre-dendritic cells (pDCs) comprise a pivotal element of antiviral immune responses. They recognize viral components, leading to type I interferon (IFN) production, and affect adaptive defense strategies designed to eliminate viral pathogens. These strategies include the ability of pDCs to modulate virus-specific CD8(+) T-cell responses. Although a great deal has been learned recently about pDCs, our knowledge of whether, how and why pDCs might function as antigen-presenting cells is extremely limited, and now is a prime time for exploring the unknowns of this area. This Opinion will focus on the IFN production and T-cell priming capacity of pDCs, and will argue that IFN production (and not T-cell priming) is the main function of pDCs during viral infection.
引用
收藏
页码:311 / 317
页数:7
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共 54 条
  • [1] Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody
    Asselin-Paturel, C
    Brizard, G
    Pin, JJ
    Brière, F
    Trinchieri, G
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 171 (12) : 6466 - 6477
  • [2] Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology
    Asselin-Paturel, C
    Boonstra, A
    Dalod, M
    Durand, I
    Yessaad, N
    Dezutter-Dambuyant, C
    Vicari, A
    O'Garra, A
    Biron, C
    Brière, F
    Trinchieri, G
    [J]. NATURE IMMUNOLOGY, 2001, 2 (12) : 1144 - 1150
  • [3] Virus-induced interferon α production by a dendritic cell subset in the absence of feedback signaling in vivo
    Barchet, W
    Cella, M
    Odermatt, B
    Asselin-Paturel, C
    Colonna, M
    Kalinke, U
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (04) : 507 - 516
  • [4] Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
    Belz, GT
    Smith, CM
    Kleinert, L
    Reading, P
    Brooks, A
    Shortman, K
    Carbone, FR
    Heath, WR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (23) : 8670 - 8675
  • [5] Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus
    Blanco, P
    Palucka, AK
    Gill, M
    Pascual, V
    Banchereau, J
    [J]. SCIENCE, 2001, 294 (5546) : 1540 - 1543
  • [6] A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha
    Blasius, A
    Vermi, W
    Krug, A
    Facchetti, F
    Cella, M
    Colonna, M
    [J]. BLOOD, 2004, 103 (11) : 4201 - 4206
  • [7] IFN-α/β enhances BCR-dependent B cell responses
    Braun, D
    Caramalho, I
    Demengeot, J
    [J]. INTERNATIONAL IMMUNOLOGY, 2002, 14 (04) : 411 - 419
  • [8] Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs
    Brawand, P
    Fitzpatrick, DR
    Greenfield, BW
    Brasel, K
    Maliszewski, CR
    De Smedt, T
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 169 (12) : 6711 - 6719
  • [9] Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein
    Brimnes, MK
    Bonifaz, L
    Steinman, RM
    Moran, TM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (01) : 133 - 144
  • [10] Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent THI polarization
    Cella, M
    Facchetti, F
    Lanzavecchia, A
    Colonna, M
    [J]. NATURE IMMUNOLOGY, 2000, 1 (04) : 305 - 310