Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy

被引：19

作者：

Yan, Liang ^{[1
]}

Tan, Yanlian ^{[1
]}

Chen, Guo ^{[1
]}

Fan, Jun ^{[1
]}

Zhang, Jun ^{[2
,3
]}

机构：

[1] Jinan Univ, Sch Med, Dept Med Biochem & Mol Biol, Guangzhou 510632, Peoples R China

[2] Univ Kansas, Med Ctr, Dept Internal Med, Div Med Oncol, Kansas City, KS 66160 USA

[3] Univ Kansas, Med Ctr, Dept Canc Biol, Kansas City, KS 66160 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期

基金：

中国国家自然科学基金;

关键词：

metabolic reprogramming; tumor microenvironment; tumor immune microenvironment; immune cells; immunosuppression; immunotherapy; TUMOR-ASSOCIATED MACROPHAGES; T-CELL SUBSETS; DENDRITIC CELLS; FATTY-ACID; GLUTAMINE-METABOLISM; REGULATORY T; MITOCHONDRIAL BIOGENESIS; GLUCOSE-METABOLISM; AMINO-ACID; C-MYC;

D O I：

10.3390/ijms221910268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways.

引用

页数：18

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