Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy

被引：19

作者：

Yan, Liang ^{[1
]}

Tan, Yanlian ^{[1
]}

Chen, Guo ^{[1
]}

Fan, Jun ^{[1
]}

Zhang, Jun ^{[2
,3
]}

机构：

[1] Jinan Univ, Sch Med, Dept Med Biochem & Mol Biol, Guangzhou 510632, Peoples R China

[2] Univ Kansas, Med Ctr, Dept Internal Med, Div Med Oncol, Kansas City, KS 66160 USA

[3] Univ Kansas, Med Ctr, Dept Canc Biol, Kansas City, KS 66160 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期

基金：

中国国家自然科学基金;

关键词：

metabolic reprogramming; tumor microenvironment; tumor immune microenvironment; immune cells; immunosuppression; immunotherapy; TUMOR-ASSOCIATED MACROPHAGES; T-CELL SUBSETS; DENDRITIC CELLS; FATTY-ACID; GLUTAMINE-METABOLISM; REGULATORY T; MITOCHONDRIAL BIOGENESIS; GLUCOSE-METABOLISM; AMINO-ACID; C-MYC;

D O I：

10.3390/ijms221910268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways.

引用

页数：18

共 157 条

[31] TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation [J].

Everts, Bart ;

Amiel, Eyal ;

Huang, Stanley Ching-Cheng ;

Smith, Amber M. ;

Chang, Chih-Hao ;

Lam, Wing Y. ;

Redmann, Veronika ;

Freitas, Tori C. ;

Blagih, Julianna ;

van der Windt, Gerritje J. W. ;

Artyomov, Maxim N. ;

Jones, Russell G. ;

Pearce, Erika L. ;

Pearce, Edward J. .

NATURE IMMUNOLOGY, 2014, 15 (04) :323-+

[32] Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth [J].

Fan, Jun ;

Lin, Ruiting ;

Xia, Siyuan ;

Chen, Dong ;

Elf, Shannon E. ;

Liu, Shuangping ;

Pan, Yaozhu ;

Xu, Haidong ;

Qian, Zhiyu ;

Wang, Mei ;

Shan, Changliang ;

Zhou, Lu ;

Lei, Qun-Ying ;

Li, Yuancheng ;

Mao, Hui ;

Lee, Benjamin H. ;

Sudderth, Jessica ;

DeBerardinis, Ralph J. ;

Zhang, Guojing ;

Owonikoko, Taofeek ;

Gaddh, Manila ;

Arellano, Martha L. ;

Khoury, Hanna J. ;

Khuri, Fadlo R. ;

Kang, Sumin ;

Doetsch, Paul W. ;

Lonial, Sagar ;

Boggon, Titus J. ;

Curran, Walter J. ;

Chen, Jing .

MOLECULAR CELL, 2016, 64 (05) :859-874

[33] Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance [J].

Fantin, Valeria R. ;

St-Pierre, Julie ;

Leder, Philip .

CANCER CELL, 2006, 9 (06) :425-434

[34] Toll-like Receptors and the Control of Immunity [J].

Fitzgerald, Katherine A. ;

Kagan, Jonathan C. .

CELL, 2020, 180 (06) :1044-1066

[35] Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE [J].

Freemerman, Alex J. ;

Johnson, Amy R. ;

Sacks, Gina N. ;

Milner, J. Justin ;

Kirk, Erin L. ;

Troester, Melissa A. ;

Macintyre, Andrew N. ;

Goraksha-Hicks, Pankuri ;

Rathmell, Jeffery C. ;

Makowski, Liza .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (11) :7884-7896

[36] Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond [J].

Ganapathy, Vadivel ;

Thangaraju, Muthusamy ;

Prasad, Puttur D. .

PHARMACOLOGY & THERAPEUTICS, 2009, 121 (01) :29-40

[37] Development of Monocytes, Macrophages, and Dendritic Cells [J].

Geissmann, Frederic ;

Manz, Markus G. ;

Jung, Steffen ;

Sieweke, Michael H. ;

Merad, Miriam ;

Ley, Klaus .

SCIENCE, 2010, 327 (5966) :656-661

[38] M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide [J].

Genin, Marie ;

Clement, Francois ;

Fattaccioli, Antoine ;

Raes, Martine ;

Michiels, Carine .

BMC CANCER, 2015, 15

[39] Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression [J].

Gerriets, Valerie A. ;

Kishton, Rigel J. ;

Johnson, Marc O. ;

Cohen, Sivan ;

Siska, Peter J. ;

Nichols, Amanda G. ;

Warmoes, Marc O. ;

de Cubas, Aguirre A. ;

Maclver, Nancie J. ;

Locasale, Jason W. ;

Turka, Laurence A. ;

Wells, Andrew D. ;

Rathmell, Jeffrey C. .

NATURE IMMUNOLOGY, 2016, 17 (12) :1459-1466

[40] Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation [J].

Gerriets, Valerie A. ;

Kishton, Rigel J. ;

Nichols, Amanda G. ;

Macintyre, Andrew N. ;

Inoue, Makoto ;

Ilkayeva, Olga ;

Winter, Peter S. ;

Liu, Xiaojing ;

Priyadharshini, Bhavana ;

Slawinska, Marta E. ;

Haeberli, Lea ;

Huck, Catherine ;

Turka, Laurence A. ;

Wood, Kris C. ;

Hale, Laura P. ;

Smith, Paul A. ;

Schneider, Martin A. ;

MacIver, Nancie J. ;

Locasale, Jason W. ;

Newgard, Christopher B. ;

Shinohara, Mari L. ;

Rathmell, Jeffrey C. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (01) :194-207

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