Do the anterior and lateral thalamic nuclei make distinct contributions to spatial representation and memory?

被引:39
作者
Clark, Benjamin J. [1 ]
Harvey, Ryan E. [1 ]
机构
[1] Univ New Mexico, Dept Psychol, Albuquerque, NM 87131 USA
关键词
Navigation; Head direction cell; Place cell; Grid cell; Limbic system; Hippocampus; HEAD DIRECTION CELLS; MORRIS WATER TASK; ASSOCIATIVE PARIETAL CORTEX; PATH-INTEGRATION; DORSAL NUCLEUS; GRID CELLS; SUBCORTICAL CONNECTIONS; ANTERODORSAL THALAMUS; HIPPOCAMPAL-FORMATION; LATERODORSAL NUCLEUS;
D O I
10.1016/j.nlm.2016.06.002
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The anterior and lateral thalamus has long been considered to play an important role in spatial and mnemonic cognitive functions; however, it remains unclear whether each region makes a unique contribution to spatial information processing. We begin by reviewing evidence from anatomical studies and electro-physiological recordings which suggest that at least one of the functions of the anterior thalamus is to guide spatial orientation in relation to a global or distal spatial framework, while the lateral thalamus serves to guide behavior in relation to a local or proximal framework. We conclude by reviewing experimental work using targeted manipulations (lesion or neuronal silencing) of thalamic nuclei during spatial behavior and single-unit recordings from neuronal representations of space. Our summary of this literature suggests that although the evidence strongly supports a working model of spatial information processing involving the anterior thalamus, research regarding the role of the lateral thalamus is limited and requires further attention. We therefore identify a number of major gaps in this research and suggest avenues of future study that could potentially solidify our understanding of the relative roles of anterior and lateral thalamic regions in spatial representation and memory. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:69 / 78
页数:10
相关论文
共 94 条
  • [1] Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions
    Aggleton, John P.
    O'Mara, Shane M.
    Vann, Seralynne D.
    Wright, Nick F.
    Tsanov, Marian
    Erichsen, Jonathan T.
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2010, 31 (12) : 2292 - 2307
  • [2] Lesions of the Fornix and Anterior Thalamic Nuclei Dissociate Different Aspects of Hippocampal-Dependent Spatial Learning: Implications for the Neural Basis of Scene Learning
    Aggleton, John P.
    Poirier, Guillaume L.
    Aggleton, Hugh S.
    Vann, Seralynne D.
    Pearce, John M.
    [J]. BEHAVIORAL NEUROSCIENCE, 2009, 123 (03) : 504 - 519
  • [3] A COMPARISON OF THE EFFECTS OF ANTERIOR THALAMIC, MAMILLARY BODY AND FORNIX LESIONS ON REINFORCED SPATIAL ALTERNATION
    AGGLETON, JP
    NEAVE, N
    NAGLE, S
    HUNT, PR
    [J]. BEHAVIOURAL BRAIN RESEARCH, 1995, 68 (01) : 91 - 101
  • [4] The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
    Aggleton, JP
    Hunt, PR
    Nagle, S
    Neave, N
    [J]. BEHAVIOURAL BRAIN RESEARCH, 1996, 81 (1-2) : 189 - 198
  • [5] Subcortical connections of the perirhinal, postrhinal, and entorhinal cortices of the rat. II. efferents
    Agster, Kara L.
    Pereira, Ines Tomas
    Saddoris, Michael P.
    Burwell, Rebecca D.
    [J]. HIPPOCAMPUS, 2016, 26 (09) : 1213 - 1230
  • [6] Dissociable effects of anterior and mediodorsal thalamic lesions on spatial goal-directed behavior
    Alcaraz, Fabien
    Naneix, Fabien
    Desfosses, Emilie
    Marchand, Alain R.
    Wolff, Mathieu
    Coutureau, Etienne
    [J]. BRAIN STRUCTURE & FUNCTION, 2016, 221 (01) : 79 - 89
  • [7] Differential effect of thalamic and cortical lesions on memory systems in the rat
    Alexinsky, T
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2001, 122 (02) : 175 - 191
  • [8] EFFECTS OF ANTERIOR OR DORSOMEDIAL THALAMIC IBOTENIC LESIONS ON LEARNING AND MEMORY IN RATS
    BERACOCHEA, DJ
    JAFFARD, R
    JARRARD, LE
    [J]. BEHAVIORAL AND NEURAL BIOLOGY, 1989, 51 (03): : 364 - 376
  • [9] Laterodorsal nucleus of the thalamus: A processor of somatosensory inputs
    Bezdudnaya, Tatiana
    Keller, Asaf
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 2008, 507 (06) : 1979 - 1989
  • [10] Grid cells in pre- and parasubiculum
    Boccara, Charlotte N.
    Sargolini, Francesca
    Thoresen, Veslemoy Hult
    Solstad, Trygve
    Witter, Menno P.
    Moser, Edvard I.
    Moser, May-Britt
    [J]. NATURE NEUROSCIENCE, 2010, 13 (08) : 987 - U112