Mechanisms involved in the expansion of Tregs during pregnancy: role of IL-2/STAT5 signalling

被引：18

作者：

Fainboim, L. ^{[1
,2
,3
]}

Arruvito, L. ^{[2
,3
]}

机构：

[1] Univ Buenos Aires, Lab Inmunogenet, Hosp Clin Jose de San Martin, Fac Med, RA-1120 Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Natl Council Sci & Technol Res, RA-1033 Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Sch Med, Dept Microbiol Parasitol & Immunol, RA-1120 Buenos Aires, DF, Argentina

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2011年 / 88卷 / 02期

关键词：

Regulatory T cell; Human reproduction; STAT-5; IL-2; REGULATORY T-CELLS; CUTTING EDGE; TGF-BETA; SPONTANEOUS-ABORTION; PATERNAL ANTIGENS; PERIPHERAL-BLOOD; FOXP3; EXPRESSION; DRIVES EXPANSION; CD4(+)CD25(+); IL-2;

D O I：

10.1016/j.jri.2010.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several studies have reported that the fine-tuning of regulatory T cells (Tregs) is required for a successful pregnancy and for the control of autoimmune diseases. Here, we review the mechanisms that control the expansion of Tregs, based on insights obtained from the study of women suffering unsuccessful pregnancies and on recent data from patients with autoimmune diseases or with chronic viral infections such as HCV. In particular, we review the role of endocrine factors and IL-2/STAT5 signalling in the impaired expansion of Tregs. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：93 / 98

页数：6

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