Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D

被引：103

作者：

Li, XR ^{[1
]}

Eriksson, U ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Stockholm Branch, S-17177 Stockholm, Sweden

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2001年 / 33卷 / 04期

关键词：

VEGF; angiogenesis; lymphangiogenesis; growth factor;

D O I：

10.1016/S1357-2725(01)00027-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factors (VEGFs) constitute a group of structurally and functionally related growth factors that modulate many important physiological functions of endothelial cells. Currently, five different mammalian VEGFs have been identified and they all show unique temporal and spatial expression patterns, receptor specificity and function. The VEGFs may play pivotal roles in formation of the vascular systems during embryonic development, in regulation of capillary growth in normal and pathological conditions in adults, and in the maintenance of the normal vasculature. In the future, the VEGFs and their receptors may become important therapeutic tools in treatment of conditions characterized by aberrant or defective formation of blood vessels and lymphatic vessels. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：421 / 426

页数：6

共 16 条

[1]

Aase K, 1999, DEV DYNAM, V215, P12, DOI 10.1002/(SICI)1097-0177(199905)215:1<12::AID-DVDY3>3.0.CO

[2]

2-N

[3] Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia [J].

Bellomo, D ;

Headrick, JP ;

Silins, GU ;

Paterson, CA ;

Thomas, PS ;

Gartside, M ;

Mould, A ;

Cahill, MM ;

Tonks, ID ;

Grimmond, SM ;

Townson, S ;

Wells, C ;

Little, M ;

Cummings, MC ;

Hayward, NK ;

Kay, GF .

CIRCULATION RESEARCH, 2000, 86 (02) :E29-E35

[4]

Ferrara N, 1999, CURR TOP MICROBIOL, V237, P1

[5] Clinical applications of angiogenic growth factors and their inhibitors [J].

Ferrara, N ;

Alitalo, K .

NATURE MEDICINE, 1999, 5 (12) :1359-1364

[6] Hyperplasia of lymphatic vessels in VEGF-C transgenic mice [J].

Jeltsch, M ;

Kaipainen, A ;

Joukov, V ;

Meng, XJ ;

Lakso, M ;

Rauvala, H ;

Swartz, M ;

Fukumura, D ;

Jain, RK ;

Alitalo, K .

SCIENCE, 1997, 276 (5317) :1423-1425

[7] Proteolytic processing regulates receptor specificity and activity of VEGF-C [J].

Joukov, V ;

Sorsa, T ;

Kumar, V ;

Jeltsch, M ;

ClaessonWelsh, L ;

Cao, YH ;

Saksela, O ;

Kalkkinen, N ;

Alitalo, K .

EMBO JOURNAL, 1997, 16 (13) :3898-3911

[8]

Joukov V, 1996, EMBO J, V15, P290

[9]

Kukk E, 1996, DEVELOPMENT, V122, P3829

[10]

MAGLIONE D, 1991, P NATL ACAD SCI USA, V88, P9271

← 1 2 →