Hantzsch synthesis of pyrazolo[1′,2′:1,2]pyrazolo[3,4-b]pyridines:: Partial agonists of the calcitonin receptor

被引：18

作者：

Boros, EE ^{[1
]}

Cowan, DJ ^{[1
]}

Cox, RF ^{[1
]}

Mebrahtu, MM ^{[1
]}

Rabinowitz, MH ^{[1
]}

Thompson, JB ^{[1
]}

Wolfe, LA ^{[1
]}

机构：

[1] GlaxoSmithKline Res & Dev Ltd, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 13期

关键词：

D O I：

10.1021/jo050370b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Small molecule calcitonin receptor agonists are of potential utility in the treatment and prevention of osteoporosis. Bicycloeneamine 1 was a useful intermediate in the synthesis of pyrazolopyridine calcitonin receptor partial agonists 2a-f. Dihydropyridines 10a-c were conveniently prepared by reaction of 1 with Knoevenagel adducts 9a-c, or in the case of 10d, by a three component reaction with 1, β-ketoester 7b, and aldehyde 8c. Oxidation of 10a-d to pyridines 11a-d and subsequent amide formation afforded the title compounds. © 2005 American Chemical Society.

引用

页码：5331 / 5334

页数：4

共 17 条

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