Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles

被引：49

作者：

Karthikeyan, Mari Sithambaram ^{[1
]}

Prasad, Dasappa Jagadeesh ^{[1
]}

Mahalinga, Manjathuru ^{[1
]}

Holla, Bantwal Shivarama ^{[1
]}

Kumari, Nalilu Suchetha ^{[2
]}

机构：

[1] Mangalore Univ, Dept Chem, Mangalore 574199, India

[2] KS Hegde Med Acad, Dept Biochem, Deralakatte 574160, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 01期

关键词：

2,4,-dichloro-5-fluorobenzoyl hydrazide; cinchoninyl hydrazide; POCl3; cyclization; 1,3,4-oxadiazoles; antimicrobial activity;

D O I：

10.1016/j.ejmech.2007.03.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic acids (9). The structures of newly synthesized compounds were characterized by spectral and elemental analyses. All the compounds were screened for their antibacterial and antifungal activities. Compounds 10a, 10d and 11g showed very good antimicrobial activity. Compound 10d showed good bactericidal and fungicidal activities. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：25 / 31

页数：7

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