IL-6 polymorphism in non-small cell lung cancer: a prognostic value?

被引:29
作者
Gomes, Monica [1 ,2 ,5 ]
Coelho, Ana [1 ,4 ,5 ]
Araujo, Antonio [2 ,3 ]
Azevedo, Andreia [6 ]
Teixeira, Ana Luisa [1 ,2 ]
Catarino, Raquel [1 ,4 ]
Medeiros, Rui [1 ,2 ,5 ]
机构
[1] Univ Porto, Mol Oncol Grp CI, Portuguese Inst Oncol, P-4100 Oporto, Portugal
[2] Univ Porto, ICBAS, Abel Salazar Inst Biomed Sci, P-4100 Oporto, Portugal
[3] Ctr Hosp Porto, Med Oncol Serv, Oporto, Portugal
[4] Univ Porto, Fac Med, P-4100 Oporto, Portugal
[5] Portuguese League Canc NRNorte, Res Dept, LPCC, Oporto, Portugal
[6] Univ Porto, Lab Proc Engn Environm Biotechnol & Energy LEPABE, Fac Engn, P-4100 Oporto, Portugal
关键词
Interleukin-6; Polymorphism; Non-small cell lung cancer; Survival; INTERLEUKIN-6; POLYMORPHISM; CIRCULATING INTERLEUKIN-6; PROMOTER POLYMORPHISM; -174G/C POLYMORPHISM; SERUM CONCENTRATIONS; SIGNALING PATHWAY; STAT3; ACTIVATION; GROWTH-FACTOR; ASSOCIATION; SURVIVAL;
D O I
10.1007/s13277-014-3006-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Lung cancer was found to be the most commonly diagnosed cancer, as well as the primary cause of cancer-related mortality for males worldwide and the second leading cause of cancer-related deaths for women. Cytokines are fundamental for several biological processes-associated malignant tumors. The IL-6 is a cytokine involved in the regulation of cellular functions including processes associated with cancer, such as proliferation, apoptosis, angiogenesis, and differentiation. Furthermore, IL-6 is a potent pleiotropic inflammatory cytokine that is considered a key growth-promoting and antiapoptotic factor. The polymorphism -aEuro parts per thousand 174G/C SNP is a G to C transition in the -174 position of the promoter region of the IL-6 gene. The aim of our study was to evaluate the influence of -174G/C polymorphism in clinical outcome of non-small cell cancer (NSCLC) patients. DNA was extracted from peripheral blood of 424 patients diagnosed with cytologically or histologically NSCLC. The characterization of IL-6 -174G/C genotypes was performed by PCR-RFLP (NlaIII). IL-6 polymorphism's genotypes were divided according to functional activity, so the G carriers (CG/GG) is the high-producer IL-6, and CC genotype is the low-producer IL-6. Regarding survival, we verify that patients with genotypes carrying the G allele (CG/GG) had a statistically significant diminished survival when compared with patients with CC genotype (62.79 and 42.31 months, respectively; P = 0.032). In the promoter region of the IL-6 gene, polymorphic variants were located and may be responsible for alterations in transcription that consequently affect serum levels of the cytokine. With our study, we demonstrated that genetic variant (-174G/G and G/C) can be responsible for changes in prognosis of NSCLC patients.
引用
收藏
页码:3679 / 3684
页数:6
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