Apoptosis-inducing factor contributes to epithelial cell apoptosis induced by enteropathogenic Escherichia coli

被引：1
|
作者：
Flynn, Andrew N. [1 ,2 ]
Wang, Arthur [2 ]
Mckay, Derek M. [2 ]
Buret, Andre G. [1 ,2 ]
机构：
[1] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada
[2] Univ Calgary, Inflammat Res Network, Calgary, AB T2N 1N4, Canada
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2011年 / 89卷 / 02期
基金：
加拿大自然科学与工程研究理事会;
关键词：
MITOCHONDRIAL RELEASE; TIGHT JUNCTIONS; INFECTION; DISRUPTION; MEMBRANE; INITIATE; PATHWAY; DEATH; AIF;
D O I：
10.1139/Y11-002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The mechanisms by which enteropathogenic Escherichia coli (EPEC) causes intestinal epithelial cell apoptosis remain unclear. We tested the hypothesis that apoptosis-inducing factor (AIF) is involved in apoptosis induced by EPEC. Infection of intestinal epithelial cells in vitro with EPEC led to the mitochondrial and cytosolic accumulation of AIF. This effect was partially dependent on caspase activity. Knockdown of AIF with siRNA blocked cellular apoptosis in response to EPEC infection, as assessed by poly(ADP-ribose) polymerase cleavage and oligonucleosome formation. Taken together, these data suggest that caspase-dependent mobilization of AIF contributes to EPEC-induced epithelial cell apoptosis.
引用
收藏
页码：143 / 148
页数：6
相关论文
共 50 条
  • [41] Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Park, SY
    Billiar, TR
    Seol, DW
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 291 (01) : 150 - 153
  • [42] An apoptosis-inducing isoform of Neu differentiation factor (NDF) identified using a novel screen for dominant, apoptosis-inducing genes
    Grimm, S
    Leder, P
    JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (06): : 1137 - 1142
  • [43] The Cellular Apoptosis Susceptibility Protein ( CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation
    Monian, Prashant
    Jiang, Xuejun
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (05) : 2379 - 2388
  • [44] Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis
    Cheung, Eric C. C.
    Joza, Nicholas
    Steenaart, Nancy A. E.
    McClellan, Kelly A.
    Neuspiel, Margaret
    McNamara, Stephen
    MacLaurin, Jason G.
    Rippstein, Peter
    Park, David S.
    Shore, Gordon C.
    McBride, Heidi M.
    Penninger, Josef M.
    Slack, Ruth S.
    EMBO JOURNAL, 2006, 25 (17): : 4061 - 4073
  • [45] Mechanism of ultraviolet radiation induced cell apoptosis: III. The role of acid sphingomyelinase, apoptosis-inducing factor and MAPK signaling pathways in UVA-induced apoptosis
    Ding Zhenhua
    Zhou Meijuan
    Chen Liyin
    Ou Chengshan
    Ling Zhaohui
    Yuan Changqing
    Proceedings of the China Association for Science and Technology, Vol 2, No 1, 2006, : 423 - 427
  • [46] Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in normal prostate epithelial cells
    Alexandre Nesterov
    Yuri Ivashchenko
    Andrew S Kraft
    Oncogene, 2002, 21 : 1135 - 1140
  • [47] Defining Allostery and Interactions Regulating Apoptosis-Inducing Factor
    Tainer, John A.
    Shen, Runze
    Ho, Chris
    Long, Winnie Z.
    Singh, Sukrit
    Burnett, Kathryn
    Hura, Greg L.
    Nix, Jay C.
    Bowman, Gregory R.
    Ellenberger, Tom
    Brosey, Chris A.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2017, 73 : A316 - A316
  • [48] Cowchock Syndrome Is Associated with a Mutation in Apoptosis-Inducing Factor
    Rinaldi, Carlo
    Grunseich, Christopher
    Sevrioukova, Irina F.
    Schindler, Alice
    Horkayne-Szakaly, Iren
    Lamperti, Costanza
    Landoure, Guida
    Kennerson, Marina L.
    Burnett, Barrington G.
    Boennemann, Carsten
    Biesecker, Leslie G.
    Ghezzi, Daniele
    Zeviani, Massimo
    Fischbeck, Kenneth H.
    AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 91 (06) : 1095 - 1102
  • [49] Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation
    Sevrioukova, Irina F.
    ANTIOXIDANTS & REDOX SIGNALING, 2011, 14 (12) : 2545 - 2578
  • [50] The crystal structure of the mouse apoptosis-inducing factor AIF
    María J. Maté
    Miguel Ortiz-Lombardía
    Brigitte Boitel
    Ahmed Haouz
    Diana Tello
    Santos A. Susin
    Josef Penninger
    Guido Kroemer
    Pedro M. Alzari
    Nature Structural Biology, 2002, 9 : 442 - 446
12345