Manipulation of the Upper Respiratory Microbiota to Reduce Incidence and Severity of Upper Respiratory Viral Infections: A Literature Review

被引:12
作者
Nesbitt, Henry [1 ]
Burke, Catherine [2 ]
Haghi, Mehra [1 ]
机构
[1] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW, Australia
[2] Univ Technol Sydney, Sch Life Sci, Sydney, NSW, Australia
关键词
respiratory; microorganism; virus; bacteria; microbiota; commensal; pathobiont; dysbiosis; AUREUS BIOFILM FORMATION; STAPHYLOCOCCUS-AUREUS; STREPTOCOCCUS-PNEUMONIAE; HAEMOPHILUS-INFLUENZAE; NASOPHARYNGEAL MICROBIOTA; MORAXELLA-CATARRHALIS; PATHOGENIC BACTERIA; HOST INTERACTIONS; VIRUS-INFECTION; TRACT;
D O I
10.3389/fmicb.2021.713703
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
There is a high incidence of upper respiratory viral infections in the human population, with infection severity being unique to each individual. Upper respiratory viruses have been associated previously with secondary bacterial infection, however, several cross-sectional studies analyzed in the literature indicate that an inverse relationship can also occur. Pathobiont abundance and/or bacterial dysbiosis can impair epithelial integrity and predispose an individual to viral infection. In this review we describe common commensal microorganisms that have the capacity to reduce the abundance of pathobionts and maintain bacterial symbiosis in the upper respiratory tract and discuss the potential and limitations of localized probiotic formulations of commensal bacteria to reduce the incidence and severity of viral infections.
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页数:11
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