Reassortment between seasonal and swine-origin H1N1 influenza viruses generates viruses with enhanced growth capability in cell culture

被引：22
作者：
Octaviani, Cassio Pontes [1 ]
Li, Chengjun [4 ]
Noda, Takeshi [2 ]
Kawaoka, Yoshihiro [1 ,2 ,3 ,4 ]
机构：
[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol,Minato Ku, Tokyo 1088639, Japan
[2] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Special Pathogens,Minato Ku, Tokyo 1088639, Japan
[3] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Kawaguchi, Saitama 3320012, Japan
[4] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Influenza Res Inst, Madison, WI 53711 USA
来源：
VIRUS RESEARCH | 2011年 / 156卷 / 1-2期
基金：
日本科学技术振兴机构;
关键词：
Influenza virus; Swine-origin; Pandemic; Seasonal; Reassortment; A VIRUS; PANDEMIC INFLUENZA; VIRULENCE; PROTEIN; TAIL;
D O I：
10.1016/j.virusres.2010.12.014
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
One year after the emergence of the 2009 influenza (H1N1) pandemic, most cases have been relatively mild; however, the possibility of enhanced viral growth ability by reassortment with seasonal viruses cannot be overlooked. Here, we show that reassortant viruses containing a seasonal H1 HA and swine-origin NA and M genes have enhanced virus growth over their wild-type parental viruses. The emergence of such viruses in nature could, therefore, represent a threat. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：147 / 150
页数：4
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