Von Willebrand disease in sub-Saharan Africa: a first severe case reported in Cameroon

被引：1

作者：

Tagny, Claude T. ^{[1
,2
]}

Balogog, Pauline N. ^{[2
]}

Boehlen, Francoise ^{[3
]}

Mbanya, Dora ^{[1
,2
]}

机构：

[1] Univ Yaounde I, Fac Med & Biomed Sci, BP 5739, Yaounde, Cameroon

[2] Univ Teaching Hosp Yaounde, Hematol & Blood Transfus Unit, Yaounde, Cameroon

[3] Univ Hosp Geneva, Div Angiol & Hemostasis, Geneva, Switzerland

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2016年 / 27卷 / 07期

关键词：

Cameroon; severe case; von Willebrand disease; MANAGEMENT; DIAGNOSIS;

D O I：

10.1097/MBC.0000000000000498

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In Cameroon, the Yaounde Hemophilia Treatment Center (HTC) has so far recorded 121 cases of hemophilia and only 10 cases of von Willebrand disease (VWD). We report the case of a 16-year-old girl, living in the north of Cameroon. She presented with severe meno-metrorrhagia, which had increased drastically within the past 3 months, associated more recently by gum bleeding and epistaxis. The coagulation screen showed a prolonged bleeding time. The clinical profile of this young girl and the findings of less than 5% for von Willebrand factor (VWF):Ag and 10% for VWF Ristocetin cofactor suggests a type 3 VWD. Screening for VWF:Ag and other inherited bleeding disorders in Cameroon is still rudimentary, and although VWD is more common than hemophilia, we report this case to highlight some of the challenges faced in resource-limited contexts.

引用

页码：835 / 837

页数：3

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