Molecular Interactions of Arterial Hypertension in Its Target Organs

被引:24
作者
Kucmierz, Joanna [1 ]
Frak, Weronika [1 ]
Mlynarska, Ewelina [1 ]
Franczyk, Beata [1 ]
Rysz, Jacek [1 ]
机构
[1] Med Univ Lodz, Dept Nephrol Hypertens & Family Med, Ul Zeromskiego 113, PL-90549 Lodz, Poland
关键词
arterial hypertension; blood pressure; renin-angiotensin-system; vascular remodeling; reactive oxygen species; matrix metalloproteinases; ENDOPLASMIC-RETICULUM STRESS; ANGIOTENSIN-ALDOSTERONE SYSTEM; OXIDATIVE STRESS; MATRIX METALLOPROTEINASES; INSULIN-RESISTANCE; BLOOD-PRESSURE; MECHANISMS; DAMAGE; INFLAMMATION; CONTRIBUTES;
D O I
10.3390/ijms22189669
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Arterial hypertension (AH) is a major risk factor for the development of cardiovascular diseases. It is estimated that the disease affects between 10% and 20% of the adult population and is responsible for 5.8% of all deaths worldwide. Several pathophysiologic factors are crucial in AH, including inappropriate activation of the renin-angiotensin-aldosterone system, oxidative stress and inflammation. The heart, kidney, brain, retina and arterial blood vessels are prime targets of hypertensive damage. Uncontrolled and untreated AH accelerates the damage to these organs and could cause their failure. Damage to these organs could also manifest as coronary heart disease, cognitive impairment, retinopathy or optic neuropathy. For better understanding, it is important to analyze molecular factors which take part in pathogenesis of AH and hypertension-related target organ damage. In our paper, we would like to focus on molecular interactions of AH in the heart, blood vessels, brain and kidneys. We focus on matrix metalloproteinases, the role of immune system, the renin-angiotensin-aldosterone system and oxidative stress in hypertensive induced organ damage.
引用
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页数:15
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