MAMMARY CARCINOMA IN A TIGER (PANTHERA TIGRIS): MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY

被引：8
作者：
Finotello, Riccardo [3 ]
Ressel, Lorenzo [3 ]
Verin, Ranieri [3 ]
Di Lollo, Simonetta [1 ]
Baroni, Gianna [1 ]
Piccinini, Renato [2 ]
Poli, Alessandro [3 ]
机构：
[1] Univ Florence, Dept Human Pathol & Oncol, I-50139 Florence, Italy
[2] Falconara Zoo, I-60015 Ancona, Italy
[3] Fac Vet Med, Dept Anim Pathol, I-56124 Pisa, Italy
来源：
JOURNAL OF ZOO AND WILDLIFE MEDICINE | 2011年 / 42卷 / 01期
关键词：
Immunohistochemistry; wildlife; mammary carcinoma; tiger; zoo animals; ENDOTHELIAL GROWTH-FACTOR; EXPRESSION; FELIDS; FEATURES; CANCER; CANINE; P53;
D O I：
10.1638/2010-0044.1
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The histologic and immunohistochemical features of a case of mammary gland carcinoma are described in a 14-yr-old female tiger (Panthero tigris). Immunoreactivity to estrogen receptor (ER), progesterone receptor (PR), tumoral protein 53 (p53), vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER-2), and cyclooxigenase-2 (COX-2) was investigated. Neoplastic cells were negative for ER, PR, and p53 but showed positivity for VEGF, HER-2, and COX-2, both in the primary and the metastatic lesions. Histopathologic findings and immunohistochemistry results suggested that the malignant behavior of the reported case could be comparable with some aggressive cat mammary carcinomas.
引用
收藏
页码：134 / 138
页数：5
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