Clonal dissemination of carbapenem-resistant Klebsiella pneumoniae ST16 co-producing NDM-1 and OXA-232 in Thailand

被引：12

作者：

Abe, Ryuichiro ^{[1
,2
]}

Akeda, Yukihiro ^{[1
,3
,4
]}

Takeuchi, Dan ^{[1
]}

Sakamoto, Noriko ^{[1
,5
]}

Sugawara, Yo ^{[1
,5
]}

Yamamoto, Norihisa ^{[3
]}

Kerdsin, Anusak ^{[6
]}

Matsumoto, Yuki ^{[7
]}

Motooka, Daisuke ^{[7
]}

Leolerd, Warawut ^{[8
]}

Santanirand, Pitak ^{[8
]}

Suzuki, Masato ^{[5
]}

Shibayama, Keigo ^{[9
]}

Tomono, Kazunori ^{[3
]}

Iida, Tetsuya ^{[1
,2
,8
,10
]}

Hamada, Shigeyuki ^{[1
]}

机构：

[1] Osaka Univ, Japan Thailand Res Collaborat Ctr Emerging & Reem, Res Inst Microbial Dis, Osaka, Japan

[2] Osaka Univ, Res Inst Microbial Dis, Dept Bacterial Infect, Osaka, Japan

[3] Osaka Univ, Grad Sch Med, Dept Infect Control & Prevent, Osaka, Japan

[4] Natl Inst Infect Dis, Dept Bacteriol 1, Tokyo, Japan

[5] Natl Inst Infect Dis, Antimicrobial Resistance Res Ctr, Tokyo, Japan

[6] Kasetsart Univ, Fac Publ Hlth, Chalermphrakiat Sakon Nakhon Prov Campus, Sakon Nakhon, Thailand

[7] Osaka Univ, Res Inst Microbial Dis, Dept Infect Metagen, Osaka, Japan

[8] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok, Thailand

[9] Natl Inst Infect Dis, Dept Bacteriol 2, Tokyo, Japan

[10] Osaka Univ, Ctr Infect Dis Educ & Res, Osaka, Japan

来源：

JAC-ANTIMICROBIAL RESISTANCE | 2022年 / 4卷 / 04期

关键词：

D O I：

10.1093/jacamr/dlac084

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Klebsiella pneumoniae ST258 and ST11 carrying bla(KPC) are among the most widespread carbapenem-resistant K. pneumoniae strains worldwide. Our carbapenem-resistant Enterobacteriaceae surveillance in Thailand revealed a nationwide dissemination of K. pneumoniae ST16 isolates carrying bla(NDM-1) and bla(OXA-232). Objectives To analyse the genomic details of this nationwide dissemination by focusing on plasmids and virulence factors. Methods Using WGS data of 119 K. pneumoniae ST16 isolates carrying bla(NDM-1) obtained in our previous surveillance study, clonality of chromosomes and plasmids of the isolates with carriage of virulence factors was evaluated. Results Of the 119 isolates, 111 carried plasmid pKP151_NDM1, and all 104 isolates harbouring bla(OXA-232) carried plasmid pKP151_OXA232. These 104 K. pneumoniae ST16 isolates showing chromosomal clonality possessed both pKP151_NDM1 and pKP151_OXA232, demonstrating clonal dissemination of K. pneumoniae ST16 with these plasmids. The isolates had essentially similar virulence factors as those of K. pneumoniae ST16 clones carrying bla(KPC), which were recently reported as highly invasive clones in Brazil. Conclusions The potential global dissemination of these invasive clones with resistance to several antibiotics highlights the importance of appropriate monitoring and strict standard precautions.

引用

页数：5

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