Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy

被引：56

作者：

Ye, Jian ^{[1
,2
]}

Peng, Guangyong ^{[1
,2
]}

机构：

[1] St Louis Univ, Sch Med, Div Infect Dis Allergy & Immunol, St Louis, MO 63103 USA

[2] St Louis Univ, Sch Med, Dept Internal Med, St Louis, MO 63103 USA

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 03期

关键词：

cAMP; immunosenescence; regulatory T cells; toll-like receptor; tumor immunotherapy; tumor microenvironment; REPLICATIVE SENESCENCE; IMMUNITY; CANCER;

D O I：

10.4161/2162402X.2014.994398

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Understanding molecular mechanisms involved in creating and sustaining the tumor suppressive microenvironment is critical for the development of novel antitumor therapeutic strategies. We have identified the induction of T cell senescence as a novel mechanism utilized by human tumor cells to induce immune suppression, and provided a new strategy using TLR8 ligands to reverse tumor immunosuppressive effects for tumor immunotherapy.

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页码：1 / 3

页数：3

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