Implementing Dried Blood Spot Sampling for Clinical Pharmacokinetic Determinations: Considerations from the IQ Consortium Microsampling Working Group

被引：52

作者：

Evans, Christopher ^{[1
]}

Arnold, Mark ^{[2
]}

Bryan, Peter ^{[3
]}

Duggan, Jeffrey ^{[4
]}

James, Christopher A. ^{[5
]}

Li, Wenkui ^{[6
]}

Lowes, Steve ^{[7
]}

Matassa, Luca ^{[8
]}

Olah, Timothy ^{[9
]}

Timmerman, Philip ^{[10
]}

Wang, Xiaomin ^{[11
]}

Wickremsinhe, Enaksha ^{[12
]}

Williams, John ^{[13
]}

Woolf, Eric ^{[14
]}

Zane, Patricia ^{[15
]}

机构：

[1] GlaxoSmithKline, PTS DMPK, Bioanalyt Sci & Toxicokinet BST, King Of Prussia, PA 19406 USA

[2] Bristol Myers Squibb Co, Bioanalyt Sci & Select Integrat, Princeton, NJ 08543 USA

[3] B2S Consulting, Mendham, NJ 07945 USA

[4] Boehringer Ingelheim Pharmaceut Inc, Bioanal & Metabolite Profiling, Ridgefield, CT 06877 USA

[5] Amgen Inc, Bioanalyt Sci, PKDM, Thousand Oaks, CA 91320 USA

[6] Novartis Inst BioMed Res, DMPK Early Bioanalyt & Technol EBT, E Hanover, NJ 07936 USA

[7] Quintiles, Bioanalyt & ADME Labs, Ithaca, NY 14850 USA

[8] Bioanalyt QPS LLC, Newark, DE USA

[9] Bristol Myers Squibb Co, Bioanalyt Res, Princeton, NJ USA

[10] Janssen Res & Dev, B-2340 Beerse, Belgium

[11] Celgene Corp, Bioanal, DMPK, Summit, NJ 07901 USA

[12] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

[13] Vertex Pharmaceut Inc, Drug Metab & Pharmacokinet, Boston, MA 02210 USA

[14] Merck & Co Inc, PPDM Global Bioanalyt, West Point, PA 19486 USA

[15] Sanofi US, Drug Disposit Safety & Anim Res DSAR, Bridgewater, NJ 08807 USA

来源：

AAPS JOURNAL | 2015年 / 17卷 / 02期

关键词：

QUANTITATIVE BIOANALYSIS; ASSAY BIAS; DBS; HEMATOCRIT; DISCOVERY; PLASMA; COLLECTION; STABILITY; MS/MS;

D O I：

10.1208/s12248-014-9695-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：292 / 300

页数：9

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