Expression Regulation and Function of T-Bet in NK Cells

被引：33

作者：

Huang, Chen ^{[1
]}

Bi, Jiacheng ^{[1
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, CAS Key Lab Quantitat Engn Biol, Shenzhen, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

国家重点研发计划;

关键词：

Tbx21; Eomes; Th1; tumor immunology; immunotherapy; NATURAL-KILLER-CELLS; IFN-GAMMA-PRODUCTION; TRANSCRIPTION FACTOR; INTERFERON-GAMMA; MYCOBACTERIUM-TUBERCULOSIS; INNATE IMMUNITY; DNA-BINDING; INFECTION; RESPONSES; BOX;

D O I：

10.3389/fimmu.2021.761920

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-gamma, IL-12, IL-15 and IL-21 through the respective cytokine receptors and downstream JAK/STATs or PI3K-AKT-mTORC1 signaling pathways. In this review, we aim to discuss the expression and regulation of T-bet in NK cells, the role of T-bet in mouse NK cell development, maturation, and function, as well as the role of T-bet in acute, chronic infection, inflammation, autoimmune diseases and tumors.

引用

页数：9

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