Expression Regulation and Function of T-Bet in NK Cells

被引：33
|
作者：
Huang, Chen [1 ]
Bi, Jiacheng [1 ]
机构：
[1] Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, CAS Key Lab Quantitat Engn Biol, Shenzhen, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
国家重点研发计划;
关键词：
Tbx21; Eomes; Th1; tumor immunology; immunotherapy; NATURAL-KILLER-CELLS; IFN-GAMMA-PRODUCTION; TRANSCRIPTION FACTOR; INTERFERON-GAMMA; MYCOBACTERIUM-TUBERCULOSIS; INNATE IMMUNITY; DNA-BINDING; INFECTION; RESPONSES; BOX;
D O I：
10.3389/fimmu.2021.761920
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-gamma, IL-12, IL-15 and IL-21 through the respective cytokine receptors and downstream JAK/STATs or PI3K-AKT-mTORC1 signaling pathways. In this review, we aim to discuss the expression and regulation of T-bet in NK cells, the role of T-bet in mouse NK cell development, maturation, and function, as well as the role of T-bet in acute, chronic infection, inflammation, autoimmune diseases and tumors.
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页数：9
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