Membrane contact sites, gateways for lipid homeostasis

被引：117

作者：

Lahiri, Sujoy ^{[1
]}

Toulmay, Alexandre ^{[1
]}

Prinz, William A. ^{[1
]}

机构：

[1] NIDDKD, Lab Cell & Mol Biol, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2015年 / 33卷

关键词：

D O I：

10.1016/j.ceb.2014.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Maintaining the proper lipid composition of cellular membranes is critical for numerous cellular processes but mechanisms of membrane lipid homeostasis are not well understood. There is growing evidence that membrane contact sites (MCSs), regions where two organelles come in close proximity to one another, play major roles in the regulation of intracellular lipid composition and distribution. MCSs are thought to mediate the exchange of lipids and signals between organelles. In this review, we discuss how lipid exchange occurs at MCSs and evidence for roles of MCSs in regulating lipid synthesis and degradation. We also discuss how networks of organelles connected by MCSs may modulate cellular lipid homeostasis and help determine organelle lipid composition.

引用

页码：82 / 87

页数：6

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