Plocoralides A-C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza

被引：28

作者：

Knott, MG

Mkwananzi, H

Arendse, CE

Hendricks, DT

Bolton, JJ

Beukes, DR

机构：

[1] Rhodes Univ, Fac Pharm, ZA-6140 Grahamstown, South Africa

[2] Univ Cape Town, Dept Bot, ZA-7701 Rondebosch, South Africa

[3] Univ Cape Town, Div Med Biochem, ZA-7701 Rondebosch, South Africa

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Plocamitan corallorhiza; halogenated monoterpenes; plocoralides;

D O I：

10.1016/j.phytochem.2005.03.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new polyhalogenated monoterpenes, plocoralides A-C (1-3) along with three known compounds (4-6) have been isolated from the organic extract of the red alga P. corallorhiza. Structures of the new compounds were characterized as 4,8-dibromo-1,1dichloro-3,7-dimethyl-2E,6E-octadiene (1), 4,6-dibromo-1,1-dichloro-3,7-dimethyl-2E,7-octadiene (2) and 4,8-dibromo-1,1,7-trichloro-3,7-dimethyl-2E,5Z-octadiene (3) on the basis of one- and two-dimensional NMR spectroscopic data and MS analyses. Compounds 2-6 show moderate cytotoxicity toward esophageal cancer cells. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1108 / 1112

页数：5

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