Isoprostanes and phytoprostanes: Bioactive lipids

被引：39
作者：
Durand, T. [1 ]
Bultel-Ponce, V. [1 ]
Guy, A. [1 ]
El Fangour, S. [1 ]
Rossi, J. -C. [1 ]
Galano, J. -M. [1 ]
机构：
[1] Univ Montpellier 2, Univ Montpellier 1, Fac Pharm, CNRS,IBMM,UMR 5247, F-34093 Montpellier 05, France
来源：
BIOCHIMIE | 2011年 / 93卷 / 01期
关键词：
Biological activity; Polyunsaturated fatty acid; Isoprostanes; Phytoprostanes; Total synthesis; PERFORMANCE LIQUID-CHROMATOGRAPHY; RADICAL-CATALYZED MECHANISM; MASS-SPECTROMETRY; OXIDATIVE STRESS; IN-VIVO; OXIDIZED LIPIDS; METHYL-ESTER; F-2-ISOPROSTANES; PLASMA; NONCYCLOOXYGENASE;
D O I：
10.1016/j.biochi.2010.05.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyunsaturated fatty acids (PUFA) are important constituents in all eukaryotic organisms, contributing to the structural integrity of biological membranes and serving as precursors for enzymatically-generated local hormones. In addition to these functions, PUFA can generate by a free radical-initiated mechanism, key products which participate in a variety of pathophysiological processes. In particular, free radical-catalyzed peroxidation of PUFA leads to in vivo formation of isoprostanes (IsoP), neuroprostanes (NeuroP), and phytoprostanes (PhytoP) which display a wide range of biological actions. IsoP are now the most reliable indicators of oxidative stress in humans. In this review, we will discuss some advances in our knowledge regarding two cyclic PUFA derivatives, IsoP and PhytoP, and how their biological roles may be clarified through new approaches based on analytical and synthetic organic chemistry. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：52 / 60
页数：9
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