Somatostatin and octreotide in acute pancreatitis: the never-ending story

被引:28
作者
Cavallini, G [1 ]
Frulloni, L [1 ]
机构
[1] Univ Verona, Policlin GB Rossi, Cattedra Gastoenterol, Dipartimento Sci Chirurg & Gastroenterol, I-37134 Verona, Italy
关键词
acute pancreatitis; octreotide; somatostatin;
D O I
10.1016/S1590-8658(01)80077-3
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The role of somatostatin and octreotide in the treatment of acute pancreatitis has been studied in the last two decades. We describe the physiologic activities of somatostatin and octreotide and their action on pancreas secretion. Results of experimental studies on the action of somatostatin and octreotide in some models of acute pancreatitis are discussed as well as the results of clinical studies on the effects of the two drugs in human acute pancreatitis. On the basis of these data, we suggest that somatostatin and octreotide should not be recommended for the prevention and treatment of acute pancreatitis.
引用
收藏
页码:192 / 201
页数:10
相关论文
共 123 条
[71]   PANCREATIC DUCT OBSTRUCTION TRIGGERS ACUTE NECROTIZING PANCREATITIS IN THE OPOSSUM [J].
LERCH, MM ;
SALUJA, AK ;
RUNZI, M ;
DAWRA, R ;
SALUJA, M ;
STEER, ML .
GASTROENTEROLOGY, 1993, 104 (03) :853-861
[72]  
LUENGO L, 1994, INT J PANCREATOL, V15, P139
[73]  
MAKHLOUF GM, 1991, TXB GASTROENTEROLOGY, P61
[74]  
Marton J, 1998, INT J PANCREATOL, V24, P203
[75]   EXPANDING USES OF OCTREOTIDE [J].
MATON, PN .
BAILLIERES CLINICAL GASTROENTEROLOGY, 1994, 8 (02) :321-337
[76]  
McKay C, 1997, INT J PANCREATOL, V21, P13
[77]   SOMATOSTATIN AND SOMATOSTATIN ANALOGS - ARE THEY INDICATED IN THE MANAGEMENT OF ACUTE-PANCREATITIS [J].
MCKAY, CJ ;
IMRIE, CW ;
BAXTER, JN .
GUT, 1993, 34 (11) :1622-1626
[78]  
MURAYAMA KM, 1990, ARCH SURG-CHICAGO, V125, P1570
[79]   EFFECT OF SOMATOSTATIN ON GALLBLADDER VOLUME AND SMALL INTESTINAL MOTOR-ACTIVITY IN HUMANS [J].
NERI, M ;
CUCCURULLO, F ;
MARZIO, L .
GASTROENTEROLOGY, 1990, 98 (02) :316-321
[80]   PANCREATIC EXOCRINE SECRETION IN ACUTE EXPERIMENTAL PANCREATITIS [J].
NIEDERAU, C ;
NIEDERAU, M ;
LUTHEN, R ;
STROHMEYER, G ;
FERRELL, LD ;
GRENDELL, JH .
GASTROENTEROLOGY, 1990, 99 (04) :1120-1127