Clinical Features and Risk Factors for Active Tuberculosis in Takayasu Arteritis: A Single-Center Case-Control Study

被引:5
作者
Zhou, Jiawei [1 ]
Ji, Ruoyu [2 ]
Zhu, Rui [3 ]
Zhou, Jingya [3 ]
Li, Jing [4 ]
Tian, Xinping [4 ]
Chen, Yuexin [1 ]
Zheng, Yuehong [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Vasc Surg, Beijing, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Dept Med Record, Peking Union Med Coll Hosp, Beijing, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Dept Rheumatol, Beijing, Peoples R China
关键词
Takayasu arteritis; tuberculosis; risk factor (RF); hsCRP; T-SPOT; TB; CLASSIFICATION;
D O I
10.3389/fimmu.2021.749317
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Backgrounds Takayasu arteritis (TAK) is a chronic, granulomatous vasculitis correlated with tuberculosis (TB). The two diseases share similar pathological characteristics and clinical manifestations which increase the difficulty to diagnose. Active tuberculosis (ATB) has implications for treatment strategies in TAK patients. Therefore, the investigation of clinical features and potential risk factors of ATB in TAK patients is vital. Methods The study reviewed hospitalized patients diagnosed with TAK in our hospital from 2008, to 2021. TAK patients with ATB were enrolled as the case group. The control group was randomly selected in a 3:1 ratio. The clinical characteristics of TAK patients with and without ATB were compared. Multivariate logistic regression analysis was performed to determine risk factors for ATB in TAK patients. Results We reviewed 1,789 patients and ultimately identified 30 (1.7%) ATB cases. TAK patients with ATB were more prone to develop symptoms including fever (p=0.001), fatigue (p=0.003), cough (p=0.037), expectoration (p < 0.001), weight loss (p=0.003), and night sweating (p < 0.001). Increased level of hypersensitive C reactive protein (hsCRP, p=0.001), decreased level of albumin (p=0.031), and higher positive rate of T-SPOT.TB test (p < 0.001) were observed in the case group. Multivariate logistic regression analysis revealed that hsCRP > 8 mg/L (OR 9.108; 95% CI, 1.096-75.711; p=0.041) and positive T-SPOT.TB result (OR 68.669; 95% CI, 7.291-646.738; p < 0.001) were risk factors for ATB in TAK patients. The proportion of patients undergoing subsequent surgery for Takayasu arteritis was lower in patients with ATB (p < 0.001). Conclusion Our study suggested that the diagnosis of ATB should be considered when TAK patients experienced symptoms including fever, fatigue, weight loss, etc. hsCRP > 8 mg/L and positive T-SPOT.TB result were identified as independent risk factors for ATB in TAK patients.
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页数:7
相关论文
共 25 条
[1]  
Afsar I, 2018, REV ESP QUIM, V31, P435
[2]  
Al-Aghbari Khaled, 2010, Heart Views, V11, P117, DOI 10.4103/1995-705X.76804
[3]  
AREND WP, 1990, ARTHRITIS RHEUM, V33, P1129
[4]   Pregnancy outcome in Takayasu arteritis [J].
Dasari, Papa ;
Gummadi, Hima Swetha .
BMJ CASE REPORTS, 2021, 14 (05)
[5]   Diagnostic standards and classification of tuberculosis in adults and children [J].
Dunlap, NE ;
Bass, J ;
Fujiwara, P ;
Hopewell, P ;
Horsburgh, CR ;
Salfinger, M ;
Simone, PM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (04) :1376-1395
[6]   Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis [J].
Garay-Baquero, Diana J. ;
White, Cory H. ;
Walker, Naomi F. ;
Tebruegge, Marc ;
Schiff, Hannah F. ;
Ugarte-Gil, Cesar ;
Morris-Jones, Stephen ;
Marshall, Ben G. ;
Manousopoulou, Antigoni ;
Adamson, John ;
Vallejo, Andres F. ;
Bielecka, Magdalena K. ;
Wilkinson, Robert J. ;
Tezera, Liku B. ;
Woelk, Christopher H. ;
Garbis, Spiros D. ;
Elkington, Paul .
JCI INSIGHT, 2020, 5 (18)
[7]   Aortitis [J].
Gornik, Heather L. ;
Creager, Mark A. .
CIRCULATION, 2008, 117 (23) :3039-3051
[8]   Angiographic findings of Takayasu arteritis: New classification [J].
Hata, A ;
Noda, M ;
Moriwaki, R ;
Numano, F .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 1996, 54 :S155-S163
[9]   TAKAYASU ARTERITIS [J].
KERR, GS ;
HALLAHAN, CW ;
GIORDANO, J ;
LEAVITT, RY ;
FAUCI, AS ;
ROTTEM, M ;
HOFFMAN, GS .
ANNALS OF INTERNAL MEDICINE, 1994, 120 (11) :919-929
[10]   Co-occurrence of Takayasu's arteritis and tuberculosis: Report of a Tunisian pediatric case [J].
Khemiri, Monia ;
Douira, Wiem ;
Barsaoui, Sihem .
ANNALS OF PEDIATRIC CARDIOLOGY, 2016, 9 (01) :75-78