For better or for worse: the role of Pim oncogenes in tumorigenesis

被引：408

作者：

Nawijn, Martijn C. ^{[1
,2
]}

Alendar, Andrej ^{[1
]}

Berns, Anton ^{[1
]}

机构：

[1] Netherlands Canc Inst, Dept Mol Genet, NL-1066 CX Amsterdam, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Lab Allergol & Pulm Dis, NL-9713 GZ Groningen, Netherlands

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 01期

关键词：

ABERRANT SOMATIC HYPERMUTATION; B-CELL LYMPHOMA; SERINE/THREONINE KINASE-ACTIVITY; CHRONIC LYMPHOCYTIC-LEUKEMIA; HUMAN PANCREATIC-CANCER; E-MU-MYC; C-MYC; GENE-EXPRESSION; PROTOONCOGENE PIM-1; UP-REGULATION;

D O I：

10.1038/nrc2986

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and epithelial origin. Pim genes encode serine/threonine kinases that have been shown to counteract the increased sensitivity to apoptosis induction that is associated with MYC-driven tumorigenesis. Recently, considerable progress has been made in characterizing the pathways of PIM-mediated survival signalling. Given the unique structure of their active site and the minimal phenotype of mice mutant for all Pim family members, these oncogenes might be promising targets for highly specific and selective drugs with favourable toxicity profiles. In this Review, we discuss the physiological functions and oncogenic activities of Pim kinases.

引用

页码：23 / 34

页数：12

共 175 条

[1] Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity [J].

Aho, Teija L. T. ;

Sandholm, Jouko ;

Peltola, Katriina J. ;

Ito, Yoshiaki ;

Koskinen, Paivi J. .

BMC CELL BIOLOGY, 2006, 7 (1)

[2] Pim-1 kinase promotes inactivation of the pro-apoptotic bad protein by phosphorylating it on the Ser112 gatekeeper site [J].

Aho, TLT ;

Sandholm, J ;

Peltola, KJ ;

Mankonen, HP ;

Lilly, M ;

Koskinen, PJ .

FEBS LETTERS, 2004, 571 (1-3) :43-49

[3] Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases pim-1 and pim-3 [J].

Aksoy, Irene ;

Sakabedoyan, Caline ;

Bourillot, Pierre-Yves ;

Malashicheva, Anna B. ;

Mancip, Jimmy ;

Knoblauch, Kenneth ;

Afanassieff, Marielle ;

Savatier, Pierre .

STEM CELLS, 2007, 25 (12) :2996-3004

[4] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[5] The survival kinases Akt and Pim as potential pharmacological targets [J].

Amaravadi, R ;

Thompson, CB .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (10) :2618-2624

[6] THE HUMAN PROTOONCOGENE PRODUCT P33PIM IS EXPRESSED DURING FETAL HEMATOPOIESIS AND IN DIVERSE LEUKEMIAS [J].

AMSON, R ;

SIGAUX, F ;

PRZEDBORSKI, S ;

FLANDRIN, G ;

GIVOL, D ;

TELERMAN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8857-8861

[7] Growth and survival mechanisms associated with perineural invasion in prostate cancer [J].

Ayala, GE ;

Dai, H ;

Ittmann, M ;

Li, R ;

Powell, M ;

Frolov, A ;

Wheeler, TM ;

Thompson, TC ;

Rowley, D .

CANCER RESEARCH, 2004, 64 (17) :6082-6090

[8] The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C [J].

Bachmann, M ;

Kosan, C ;

Xing, PX ;

Montenarh, M ;

Hoffmann, I ;

Möröy, T .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2006, 38 (03) :430-443

[9] The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1) -: A novel role for Pim-1 at the G2/M cell cycle checkpoint [J].

Bachmann, M ;

Hennemann, H ;

Xing, PX ;

Hoffmann, I ;

Möröy, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (46) :48319-48328

[10] Adipocytes Impair Leukemia Treatment in Mice [J].

Behan, James W. ;

Yun, Jason P. ;

Proektor, Marina P. ;

Ehsanipour, Ehsan A. ;

Arutyunyan, Anna ;

Moses, Ara S. ;

Avramis, Vassilios I. ;

Louie, Stan G. ;

Butturini, Anna ;

Heisterkamp, Nora ;

Mittelman, Steven D. .

CANCER RESEARCH, 2009, 69 (19) :7867-7874

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