For better or for worse: the role of Pim oncogenes in tumorigenesis

被引：399
|
作者：
Nawijn, Martijn C. [1 ,2 ]
Alendar, Andrej [1 ]
Berns, Anton [1 ]
机构：
[1] Netherlands Canc Inst, Dept Mol Genet, NL-1066 CX Amsterdam, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Lab Allergol & Pulm Dis, NL-9713 GZ Groningen, Netherlands
来源：
NATURE REVIEWS CANCER | 2011年 / 11卷 / 01期
关键词：
ABERRANT SOMATIC HYPERMUTATION; B-CELL LYMPHOMA; SERINE/THREONINE KINASE-ACTIVITY; CHRONIC LYMPHOCYTIC-LEUKEMIA; HUMAN PANCREATIC-CANCER; E-MU-MYC; C-MYC; GENE-EXPRESSION; PROTOONCOGENE PIM-1; UP-REGULATION;
D O I：
10.1038/nrc2986
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pim oncogenes are overexpressed in a wide range of tumours from a haematological and epithelial origin. Pim genes encode serine/threonine kinases that have been shown to counteract the increased sensitivity to apoptosis induction that is associated with MYC-driven tumorigenesis. Recently, considerable progress has been made in characterizing the pathways of PIM-mediated survival signalling. Given the unique structure of their active site and the minimal phenotype of mice mutant for all Pim family members, these oncogenes might be promising targets for highly specific and selective drugs with favourable toxicity profiles. In this Review, we discuss the physiological functions and oncogenic activities of Pim kinases.
引用
收藏
页码：23 / 34
页数：12
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