Mechanisms and regulation of endothelial VEGF receptor signalling

被引：1182

作者：

Simons, Michael ^{[1
]}

Gordon, Emma ^{[2
,3
]}

Claesson-Welsh, Lena ^{[2
,3
]}

机构：

[1] Yale Cardiovasc Res Ctr, 300 George St, New Haven, CT 06511 USA

[2] Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjoldsv 20, S-75185 Uppsala, Sweden

[3] Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Dag Hammarskjoldsv 20, S-75185 Uppsala, Sweden

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 10期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR RECEPTOR-1; PROTEIN-KINASE-C; LIGAND-INDEPENDENT ACTIVATION; LYMPHATIC NETWORK FORMATION; A-DEPENDENT ACTIVATION; TYROSINE KINASE; CELL-MIGRATION; PHYSIOLOGICAL FUNCTIONS; SPROUTING ANGIOGENESIS; INHIBITS ANGIOGENESIS;

D O I：

10.1038/nrm.2016.87

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely required to balance the formation of new blood vessels with the maintenance and remodelling of existing ones, during development and in adult tissues. Recent advances have greatly expanded our understanding of the tight and multi-level regulation of VEGFR2 signalling, which is the primary focus of this Review. Important insights have been gained into the regulatory roles of VEGFR-interacting proteins (such as neuropilins, proteoglycans, integrins and protein tyrosine phosphatases); the dynamics of VEGFR2 endocytosis, trafficking and signalling; and the crosstalk between VEGF-induced signalling and other endothelial signalling cascades. A clear understanding of this multifaceted signalling web is key to successful therapeutic suppression or stimulation of vascular growth.

引用

页码：611 / 625

页数：15

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