HIV-1 drug-resistance and drug-dependence

被引：23

作者：

Baldwin, Chris ^{[1
]}

Berkhout, Ben ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, Lab Expt Virol,CINIMA, NL-1012 WX Amsterdam, Netherlands

来源：

RETROVIROLOGY | 2007年 / 4卷 / 1期

关键词：

D O I：

10.1186/1742-4690-4-78

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this review, we will describe several recent HIV-1 studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First, the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second, a compensatory mutation that repairs the protein function, but in the presence of the drug, which becomes an intrinsic part of the mechanism. The clinical relevance of drug-dependent HIV-1 variants is also discussed.

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