Orthogonal selectivity with cinnamic acids in 3-substituted benzofuran synthesis through C-H olefination of phenols

被引：59

作者：

Agasti, Soumitra ^{[1
]}

Sharma, Upendra ^{[1
]}

Naveen, Togati ^{[1
]}

Maiti, Debabrata ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 25期

关键词：

UNACTIVATED INTERNAL ALKYNES; MARINE SPONGE; OXIDATIVE ANNULATION; CARBOXYLIC-ACIDS; ARYL CHLORIDES; HECK REACTIONS; OXIME ESTERS; IANTHELLA SP; O-ARYLATION; INHIBITORS;

D O I：

10.1039/c4cc07026g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium catalyzed intermolecular annulation of cinnamic acids and phenols has been achieved for the selective synthesis of 3-substituted benzofurans. Isotope labeling, competition experiments, kinetic studies, and intermediate trapping have supported a sequence of C-C bond formation and decarboxylation followed by the C-O cyclization pathway.

引用

页码：5375 / 5378

页数：4

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