Biodistribution of technetium-99m pertechnetate after total colectomy in rats

被引：4

作者：

Meneses Rego, Amalia Cinthia ^{[1
]}

Oliveira Ramalho, Rachel Alcantara ^{[1
]}

Tabosa Egito, Eryvaldo Socrates ^{[1
]}

Araujo-Filho, Irami ^{[1
]}

Azevedo, Itato Medeiros ^{[1
]}

Palestro, Christopher J. ^{[2
,3
]}

Medeiros, Aldo Cunha ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Norte, Postgrad Program Hlth Sci, BR-59078270 Natal, RN, Brazil

[2] N Shore Long Isl Jewish Hlth Syst, Div Nucl Med & Mol Imaging, Manhasset, NY USA

[3] N Shore Long Isl Jewish Hlth Syst, Div Nucl Med & Mol Imaging, New Hyde Pk, NY USA

来源：

APPLIED RADIATION AND ISOTOPES | 2010年 / 68卷 / 12期

关键词：

Total colectomy; Pertechnetate; Technetium-99m; Biological availability; Rats; TOTAL MESORECTAL EXCISION; POUCH-ANAL ANASTOMOSIS; RADIOPHARMACEUTICAL SODIUM PERTECHNETATE; ILEORECTAL ANASTOMOSIS; RESTORATIVE PROCTOCOLECTOMY; SMALL-INTESTINE; RECTAL-CANCER; WISTAR RATS; BALB/C MICE; BOWEL;

D O I：

10.1016/j.apradiso.2010.07.015

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This study evaluated the effects of total colectomy on the biodistribution of technetium-99m pertechnetate (99(m)TcO(4)(-)) on the 28th postoperative day in rats Samples of several organs were harvested for counting the percent of injected radioactivity/g of tissue (%ATI/g). The %ATI/g in colectomy rats was higher in the stomach and ileum than in sham and controls (p<0.05). Increase in mucosa and muscularis size of ileum was observed. Colectomy was associated with lower biodistribution in bladder and thyroid. T3, and T4, than in controls. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2169 / 2173

页数：5

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