High levels of interferon gamma in the plasma of children with complete interferon gamma receptor deficiency

被引：54
作者：
Fieschi, C
Dupuis, S
Picard, C
Smith, CIE
Holland, SM
Casanova, JL
机构：
[1] Necker Enfants Malad Med Sch, Lab Human Genet Infect Dis, F-75015 Paris, France
[2] Karolinska Inst, Huddinge, Sweden
[3] NIH, Host Def Lab, Bethesda, MD 20892 USA
[4] Necker Enfants Malad Med Sch, Pediat Immunol Unit, F-75015 Paris, France
来源：
PEDIATRICS | 2001年 / 107卷 / 04期
关键词：
interferon gamma; mycobacteria; genetic susceptibility; immunodeficiency; plasma;
D O I：
10.1542/peds.107.4.e48
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We have found that children with complete interferon gamma (IFN gamma) receptor deficiency, unlike patients with other genetic defects predisposing them to mycobacterial diseases, have very high levels of IFN gamma in their plasma. This unexpected observation provides a simple and accurate diagnostic method for complete IFN gamma receptor deficiency in children with clinical disease caused by bacille Calmette-Guerin vaccines or environmental nontuberculous mycobacteria.
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收藏
页码：art. no. / e48
页数：3
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