Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics

被引：53
|
作者：
Sadhasivam, S. [1 ,2 ]
Chidambaran, V. [1 ,2 ]
Zhang, X. [2 ,3 ]
Meller, J. [2 ,4 ]
Esslinger, H. [1 ]
Zhang, K. [2 ,3 ]
Martin, L. J. [2 ,3 ]
McAuliffe, J. [1 ,2 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Dept Anesthesia, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Human Genet, Cincinnati, OH 45229 USA
[4] Cincinnati Childrens Hosp Med Ctr, Div Bioinformat, Cincinnati, OH 45229 USA
来源：
PHARMACOGENOMICS JOURNAL | 2015年 / 15卷 / 02期
关键词：
GENE POLYMORPHISMS; CHILDREN; MORPHINE; TONSILLECTOMY; ASSOCIATION; PAIN; ADENOTONSILLECTOMY; HOSPITALIZATIONS; GENOTYPE; PLASMA;
D O I：
10.1038/tpj.2014.56
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Opioid-related respiratory depression (RD) is a serious clinical problem as it causes multiple deaths and anoxic brain injuries. Morphine is subject to efflux via P-glycoprotein transporter encoded by ABCB1, also known as MDR1. ABCB1 polymorphisms may affect blood-brain barrier transport of morphine and therefore individual response to its central analgesic and adverse effects. This study aimed to determine specific associations between common ABCB1 genetic variants and clinically important outcomes including RD and RD resulting in prolonged stay in hospital with intravenous morphine in a homogenous pediatric surgical pain population of 263 children undergoing tonsillectomy. Children with GG and GA genotypes of ABCB1 polymorphism rs9282564 had higher risks of RD resulting in prolonged hospital stays; adding one copy of the minor allele (G) increased the odds of prolonged hospital stay due to postoperative RD by 4.7-fold (95% confidence interval: 2.1-10.8, P = 0.0002).
引用
收藏
页码：119 / 126
页数：8
相关论文
共 50 条
  • [21] Intranasal leptin prevents opioid-induced respiratory depression
    Freire, Carla
    Pho, Huy
    Kim, Lenise
    Wang, Xin
    Dyavanapalli, Jhansi
    Streeter, Stone
    Fleury-Curado, Thomaz
    Mendelowitz, David
    Polotsky, Vsevolod Y.
    EUROPEAN RESPIRATORY JOURNAL, 2020, 56
  • [22] Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression
    Dahan, Albert
    Aarts, Leon
    Smith, Terry W.
    ANESTHESIOLOGY, 2010, 112 (01) : 226 - 238
  • [23] Risk Factors for Opioid-Induced Excessive Respiratory Depression
    Jungquist, Carla R.
    Karan, Suzanne
    Perlis, Michael L.
    PAIN MANAGEMENT NURSING, 2011, 12 (03) : 180 - 187
  • [24] ABCB1 pharmacogenetics:: Progress, pitfalls, and promise
    Chinn, L. W.
    Kroetz, D. L.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2007, 81 (02) : 265 - 269
  • [25] Respiratory Volume Variability Prior To Opioid Administration As An Indicator For Opioid-Induced Respiratory Depression
    Cattano, D.
    Brayanov, J.
    George, E.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191
  • [26] Regulation of the ABCB1 transporter by MARCKS
    Wenzel, T.
    Buech, T.
    Schaefer, M.
    Kalwa, H.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2016, 389 (01) : S62 - S62
  • [27] Pharmacogenetics and Treatment Response in Narcolepsy Type 1: Relevance of the Polymorphisms of the Drug Transporter Gene ABCB1
    Moresco, Monica
    Riccardi, Laura Natalia
    Pizza, Fabio
    Zenesini, Corrado
    Caporali, Leonardo
    Plazzi, Giuseppe
    Pelotti, Susi
    CLINICAL NEUROPHARMACOLOGY, 2016, 39 (01) : 18 - 23
  • [28] Averting Opioid-induced Respiratory Depression without Affecting Analgesia
    Dahan, Albert
    van der Schrier, Rutger
    Smith, Terry
    Aarts, Leon
    van Velzen, Monique
    Niesters, Marieke
    ANESTHESIOLOGY, 2018, 128 (05) : 1027 - 1037
  • [29] Postoperative Opioid-Induced Respiratory Depression: 3 Steps Forward
    Prielipp, Richard C.
    Fulesdi, Bela
    Brull, Sorin J.
    ANESTHESIA AND ANALGESIA, 2020, 131 (04): : 1007 - 1011
  • [30] A shock to the system: neurostimulation therapy for opioid-induced respiratory depression
    O'Halloran, Ken D.
    JOURNAL OF PHYSIOLOGY-LONDON, 2022, 600 (12): : 2833 - 2834
12345