MicroRNA: Defining a new niche in Leukemia

被引：17
作者：
Fernandes, Queenie [1 ]
机构：
[1] Hamad Med Corp, POB 4572, Doha, Qatar
来源：
BLOOD REVIEWS | 2017年 / 31卷 / 03期
关键词：
MicroRNAs; Biomarkers; Leukemia; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; EXPRESSION SIGNATURES; TUMOR-SUPPRESSOR; DOWN-REGULATION; CELL-DIFFERENTIATION; MIR-17-92; CLUSTER; INDUCE APOPTOSIS; SMALL RNAS; MIRNA;
D O I：
10.1016/j.blre.2016.11.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
MicroRNAs (miRNAs) are endogenous short non-coding RNAs found to play key roles in the pathogenesis of leukemia. Apart from being traditionally identified as modulators of oncogenes, the potential roles of miRNAs seems to be growing with novel and recent findings among different subtypes of hematological malignancies. Leukemia is one of the earliest malignancies to be linked to abnormal expression of miRNAs. However, a clear understanding of the involvement of miRNAs in intricate mechanisms of leukemogenesis is still a necessity. This review summarizes the multiple roles of miRNAs in the pathogenesis of leukemia and highlights major research findings contributing to these aspects. (C) 2016 Elsevier Ltd. All rights reserved.
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收藏
页码：129 / 138
页数：10
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