Recent Advances of Fluorescence Probes for Imaging of Ferroptosis Process

被引：18

作者：

Li, Hongyu ^{[1
,2
,3
,4
]}

An, Yan ^{[1
,2
,3
,4
]}

Gao, Jie ^{[1
,2
,3
,4
]}

Yang, Mingyan ^{[1
,2
,3
,4
]}

Luo, Junjun ^{[1
,2
,3
,4
]}

Li, Xinmin ^{[1
,2
,3
,4
]}

Lv, Jiajia ^{[1
,2
,3
,4
]}

Li, Xiaohua ^{[5
]}

Yuan, Zeli ^{[1
,2
,3
,4
]}

Ma, Huimin ^{[5
]}

机构：

[1] Zunyi Med Univ, Coll Pharm, Zunyi 563003, Guizhou, Peoples R China

[2] Zunyi Med Univ, Minist Educ, Key Lab Basic Pharmacol, Zunyi 563000, Guizhou, Peoples R China

[3] Zunyi Med Univ, Minist Educ, Joint Int Res Lab Ethnomed, Zunyi 563000, Guizhou, Peoples R China

[4] Guizhou Int Sci & Technol Cooperat Base Med Photo, Zunyi 563003, Guizhou, Peoples R China

[5] Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China

来源：

CHEMOSENSORS | 2022年 / 10卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ferroptosis; fluorescence probe; iron; reactive oxygen species; biothiols; intracellular microenvironment; LABILE IRON; CELL-DEATH; LIPID-PEROXIDATION; OXIDATIVE STRESS; REACTIVE OXYGEN; RADICALS; STATES;

D O I：

10.3390/chemosensors10060233

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Ferroptosis is an iron-dependent form of regulated cell death. It has attracted more and more research interests since it was found because of its potential physiological and pathological roles. In recent years, many efforts have been made for the developments and applications of selective fluorescence probes for real-time and in situ tracking of bioactive species during ferroptosis process, which is necessary and significant to further study the modulation mechanisms and pathological functions of ferroptosis. In this review, we will focus on summarizing the newly developed fluorescence probes that have been applied for ferroptosis imaging in the recent years, and comprehensively discussing their design strategies, including the probes for iron, reactive oxygen species, biothiols and intracellular microenvironmental factors.

引用

页数：23

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