New Metabolites from the Endophytic Fungus Mollisia sp.

被引：8

作者：

Fan, Nai Wen ^{[1
]}

Chang, Hsun Shuo ^{[1
,2
]}

Cheng, Ming Jen ^{[3
]}

Chan, Hing Yuen ^{[3
]}

Hsieh, Sung Yuan ^{[3
]}

Liu, Ta Wei ^{[3
]}

Chen, Sheng Wen ^{[4
]}

Yuan, Gwo Fang ^{[3
]}

Chen, Ih Sheng ^{[2
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[3] Food Ind Res & Dev Inst, BCRC, Hsinchu 300, Taiwan

[4] Kaohsiung Med Univ, Coll Pharm, Dept Fragrance & Cosmet Sci, Kaohsiung 807, Taiwan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2016年 / 52卷 / 04期

关键词：

Mollisia sp; Dermateaceae; aliphatic derivatives; gamma-lactone; secondary metabolites; NATURAL-PRODUCTS; MICROORGANISMS; BACTERIA; STRAIN; PLANTS; ACIDS;

D O I：

10.1007/s10600-016-1718-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new metabolites, mollisinols A and B (1 and 2), and one first isolated from nature, mollisilactone (3), along with 13 known compounds (4-16), were isolated from the EtOAc-soluble fraction of the solid-state fermentation of the endophytic fungus Mollisia sp., derived from the root bark of Ardisia cornudentata Mez (Myrsinaceae). Their structures were elucidated by spectroscopic analyses, including 1D and 2D NMR experiments, and by HR-ESI-MS mass spectrometry. Among the isolates, ergosterol peroxide (12) inhibited NO production in activated macrophages, and emodin (8) showed IL-6 inhibitory activity in LPS activated RAW 264.7 cells with IC50 values of 36.99 and 5.97 mu M, respectively.

引用

页码：585 / 590

页数：6

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