Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

被引：34

作者：

Coussens, Nathan P. ^{[1
]}

Sittampalam, G. Sitta ^{[1
]}

Guha, Rajarshi ^{[1
]}

Brimacombe, Kyle ^{[1
]}

Grossman, Abigail ^{[1
]}

Chung, Thomas D. Y. ^{[2
]}

Weidner, Jeffrey R. ^{[3
]}

Riss, Terry ^{[4
]}

Trask, O. Joseph ^{[5
]}

Auld, Douglas ^{[6
]}

Dahlin, Jayme L. ^{[7
]}

Devanaryan, Viswanath ^{[8
]}

Foley, Timothy L. ^{[9
]}

Mcgee, James ^{[10
]}

Kahl, Steven D. ^{[10
]}

Kales, Stephen C. ^{[1
]}

Arkin, Michelle ^{[11
]}

Baell, Jonathan ^{[12
]}

Bejcek, Bruce ^{[13
]}

Gal-Edd, Neely ^{[14
]}

Glicksman, Marcie ^{[15
]}

Haas, Joseph V. ^{[10
]}

Iversen, Philip W. ^{[10
]}

Hoeppner, Marilu ^{[16
]}

Lathrop, Stacy ^{[16
]}

Sayers, Eric ^{[16
]}

Liu, Hanguan ^{[16
]}

Trawick, Bart ^{[16
]}

Mcvey, Julie ^{[16
]}

Lemmon, Vance P. ^{[17
]}

Li, Zhuyin ^{[18
]}

McManus, Owen ^{[19
]}

Minor, Lisa ^{[20
]}

Napper, Andrew ^{[21
]}

Wildey, Mary Jo ^{[22
]}

Pacifici, Robert ^{[23
]}

Chin, William W. ^{[24
]}

Xia, Menghang ^{[1
]}

Xu, Xin ^{[1
]}

Lal-Nag, Madhu ^{[1
]}

Hall, Matthew D. ^{[1
]}

Michael, Sam ^{[1
]}

Inglese, James ^{[1
]}

Simeonov, Anton ^{[1
]}

Austin, Christopher P. ^{[1
]}

机构：

[1] NIH, Natl Ctr Adv Translat Sci, Rockville, MD 20852 USA

[2] Sanford Burnham Prebys Med Discovery Inst, Conrad Prebys Ctr Chem Genom, La Jolla, CA USA

[3] QualSci Consulting LLC, Carmel, IN USA

[4] Promega Corp, Madison, WI USA

[5] PerkinElmer Inc, Waltham, MA USA

[6] Novartis Inst Biomed Res, Cambridge, MA USA

[7] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[8] Charles River Labs, Souderton, PA USA

[9] Pfizer Worldwide Res & Dev, Groton, CT USA

[10] Eli Lilly & Co, Indianapolis, IN 46285 USA

[11] Univ Calif San Francisco, Dept Pharmaceut Chem, Small Mol Discovery Ctr, San Francisco, CA USA

[12] Monash Univ, Med Chem, Monash Inst Pharmaceut Sci, Parkville, Vic, Australia

[13] Western Michigan Univ, Dept Biol Sci, Kalamazoo, MI 49008 USA

[14] MacroGenics Inc, Rockville, MD USA

[15] Orig3n, Boston, MA USA

[16] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

[17] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA

[18] Bristol Myers Squibb, Lead Discovery & Optimizat, Princeton, NJ USA

[19] Q State Biosci, Cambridge, MA USA

[20] In Vitro Strategies LLC, Flemington, NJ USA

[21] FLX Bio Inc, San Francisco, CA USA

[22] Merck Res Labs, Kenilworth, NJ USA

[23] CHDI Fdn Inc, CHDI Management Inc, Los Angeles, CA USA

[24] Harvard Med Sch, Boston, MA USA

来源：

CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2018年 / 11卷 / 05期

关键词：

PROBES; RATIO;

D O I：

10.1111/cts.12570

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a testing funnel of assays to identify genuine hits using high-throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.

引用

页码：461 / 470

页数：10

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