The bright side of dark matter: lncRNAs in cancer

被引：378

作者：

Evans, Joseph R. ^{[1
]}

Feng, Felix Y. ^{[1
,2
,3
,4
,5
,6
]}

Chinnaiyan, Arul M. ^{[2
,7
,8
,9
]}

机构：

[1] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[3] UCSF, Dept Radiat Oncol, San Francisco, CA USA

[4] UCSF, Dept Urol, San Francisco, CA USA

[5] UCSF, Dept Med, San Francisco, CA USA

[6] UCSF, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[7] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[9] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2016年 / 126卷 / 08期

关键词：

LONG NONCODING RNA; PROSTATE-CANCER; CELL-PROLIFERATION; CHROMATIN STATE; POOR-PROGNOSIS; LUNG-CANCER; GENE; MEG3; CARCINOMA; HOTAIR;

D O I：

10.1172/JCI84421

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The traditional view of genome organization has been upended in the last decade with the discovery of vast amounts of non-protein-coding transcription. After initial concerns that this "dark matter" of the genome was transcriptional noise, it is apparent that a subset of these noncoding RNAs are functional. Long noncoding RNA (lncRNA) genes resemble protein-coding genes in several key aspects, and they have myriad molecular functions across many cellular pathways and processes, including oncogenic signaling. The number of lncRNA genes has recently been greatly expanded by our group to triple the number of protein-coding genes; therefore, lncRNAs are likely to play a role in many biological processes. Based on their large number and expression specificity in a variety of cancers, lncRNAs are likely to serve as the basis for many clinical applications in oncology.

引用

页码：2775 / 2782

页数：8

共 100 条

[1] Promoter Analysis Reveals Globally Differential Regulation of Human Long Non-Coding RNA and Protein-Coding Genes [J].

Alam, Tanvir ;

Medvedeva, Yulia A. ;

Jia, Hui ;

Brown, James B. ;

Lipovich, Leonard ;

Bajic, Vladimir B. .

PLOS ONE, 2014, 9 (10)

[2]

Arita T, 2013, ANTICANCER RES, V33, P3185

[3] Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss [J].

Arun, Gayatri ;

Diermeier, Sarah ;

Akerman, Martin ;

Chang, Kung-Chi ;

Wilkinson, J. Erby ;

Hearn, Stephen ;

Kim, Youngsoo ;

MacLeod, A. Robert ;

Krainer, Adrian R. ;

Norton, Larry ;

Brogi, Edi ;

Egeblad, Mikala ;

Spector, David L. .

GENES & DEVELOPMENT, 2016, 30 (01) :34-51

[4] Ultraconserved elements in the human genome [J].

Bejerano, G ;

Pheasant, M ;

Makunin, I ;

Stephen, S ;

Kent, WJ ;

Mattick, JS ;

Haussler, D .

SCIENCE, 2004, 304 (5675) :1321-1325

[5] A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition [J].

Beltran, Manuel ;

Puig, Isabel ;

Pena, Cristina ;

Miguel Garcia, Jose ;

Belen Alvarez, Ana ;

Pena, Raul ;

Bonilla, Felix ;

Garcia de Herreros, Antonio .

GENES & DEVELOPMENT, 2008, 22 (06) :756-769

[6] Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol [J].

Bhan, Arunoday ;

Hussain, Imran ;

Ansari, Khairul I. ;

Kasiri, Sahba ;

Bashyal, Aarti ;

Mandal, Subhrangsu S. .

JOURNAL OF MOLECULAR BIOLOGY, 2013, 425 (19) :3707-3722

[7] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

[8] Noise in eukaryotic gene expression [J].

Blake, WJ ;

Kærn, M ;

Cantor, CR ;

Collins, JJ .

NATURE, 2003, 422 (6932) :633-637

[9] microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer [J].

Braconi, C. ;

Kogure, T. ;

Valeri, N. ;

Huang, N. ;

Nuovo, G. ;

Costinean, S. ;

Negrini, M. ;

Miotto, E. ;

Croce, C. M. ;

Patel, T. .

ONCOGENE, 2011, 30 (47) :4750-4756

[10] Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses [J].

Cabili, Moran N. ;

Trapnell, Cole ;

Goff, Loyal ;

Koziol, Magdalena ;

Tazon-Vega, Barbara ;

Regev, Aviv ;

Rinn, John L. .

GENES & DEVELOPMENT, 2011, 25 (18) :1915-1927

← 1 2 3 4 5 6 7 8 9 10 →