N-arylimidazole synthesis by cross-cycloaddition of isocyanides using a novel catalytic system

被引：45

作者：

Bonin, Marc-Andre ^{[1
]}

Giguere, Denis ^{[1
]}

Roy, Rene ^{[1
]}

机构：

[1] Univ Quebec, Dept Chem, Montreal, PQ H3C 3P8, Canada

来源：

TETRAHEDRON | 2007年 / 63卷 / 23期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.tet.2007.03.152

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct catalytic synthesis of N-arylimidazoles starting from the corresponding N-arylformamides and N-formylglycine esters is described. Application to different aryl substituted electron-withdrawing and -donating groups provided the analogous heterocyclic compounds in very high yields. The use of copper(I) oxide/proline catalysts allowed the reactions to proceed at room temperature. The first synthesis of N-arylimidazole bearing carbohydrate moieties is also described. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4912 / 4917

页数：6

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