Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair

被引:14
作者
Matta, Jaime [1 ,2 ,3 ,4 ]
Ortiz, Carmen [1 ,2 ,3 ,4 ]
Encarnacion, Jarline [1 ,2 ,3 ,4 ]
Dutil, Julie [1 ,2 ,3 ,4 ]
Suarez, Erick [5 ]
机构
[1] Ponce Hlth Sci Univ, Sch Med, Ponce Res Inst, Dept Basic Sci,Div Pharmacol, Ponce, PR 00716 USA
[2] Ponce Hlth Sci Univ, Sch Med, Ponce Res Inst, Dept Basic Sci,Div Toxicol, Ponce, PR 00716 USA
[3] Ponce Hlth Sci Univ, Sch Med, Ponce Res Inst, Dept Basic Sci,Div Biochem, Ponce, PR 00716 USA
[4] Ponce Hlth Sci Univ, Sch Med, Ponce Res Inst, Dept Basic Sci,Div Canc Biol, Ponce, PR 00716 USA
[5] Univ Puerto Rico, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, Med Sci Campus, San Juan, PR 00936 USA
基金
美国国家卫生研究院;
关键词
breast cancer; molecular subtypes; phenotypic variability; DNA repair capacity; multinomial regression analysis; precision medicine; CLINICAL-PRACTICE GUIDELINE; CELL REACTIVATION ASSAY; AMERICAN SOCIETY; WOMEN; SURVIVAL; THERAPY; RISK; LYMPHOCYTES; RECURRENCE; CARCINOMA;
D O I
10.3390/ijms18071505
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Breast cancer (BC) is a heterogeneous disease which many studies have classified in at least four molecular subtypes: Luminal A, Luminal B, HER2-Enriched, and Basal-like (including triple-negative breast cancer, TNBC). These subtypes provide information to stratify patients for better prognostic predictions and treatment selection. Individuals vary in their sensitivities to carcinogens due to differences in their DNA repair capacity (DRC) levels. Although our previous case-control study established low DRC (in terms of NER pathway) as a BC risk factor, we aim to study this effect among the molecular subtypes. Therefore, the objectives of this study include investigating whether DRC varies among molecular subtypes and testing any association regarding DRC. This study comprised 267 recently diagnosed women with BC (cases) and 682 without BC (controls). Our results show a substantial variability in DRC among the molecular subtypes, with TNBC cases (n = 47) having the lowest DRC (p-value < 0.05). Almost 80 percent of BC cases had a DRC below the median (4.3%). Low DRC was strongly associated with the TNBC subtype (OR 7.2; 95% CI 3.3, 15.7). In conclusion, our study provides the first report on the variability among the molecular subtypes and provides a hypothesis based on DRC levels for the poor prognosis of TNBC.
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页数:11
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