Dengue virus life cycle: viral and host factors modulating infectivity

被引：305

作者：

Rodenhuis-Zybert, Izabela A. ^{[1
]}

Wilschut, Jan ^{[1
]}

Smit, Jolanda M. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol, Mol Virol Sect, NL-9700 RB Groningen, Netherlands

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 16期

关键词：

Dengue; Flavivirus; Life cycle; Immune response; Pathogenesis; Host factors; Virulence; Antibody-dependent enhancement; WEST-NILE-VIRUS; ANTIBODY-DEPENDENT ENHANCEMENT; BORNE ENCEPHALITIS-VIRUS; T-CELL RESPONSES; NONSTRUCTURAL GLYCOPROTEIN NS1; DIFFERENT DISEASE SEVERITIES; AEDES-AEGYPTI MOSQUITOS; INDUCED LETHAL DISEASE; NECROSIS-FACTOR-ALPHA; HUMAN DENDRITIC CELLS;

D O I：

10.1007/s00018-010-0357-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50-100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious life cycle of DENV and will discuss the viral and host factors that are important in controlling DENV infection.

引用

页码：2773 / 2786

页数：14

共 212 条

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