Preventive Treatment for Household Contacts of Drug-Susceptible Tuberculosis Patients

被引：7

作者：

Salazar-Austin, Nicole ^{[1
]}

Mulder, Christiaan ^{[2
,3
]}

Hoddinott, Graeme ^{[4
]}

Ryckman, Theresa ^{[5
]}

Hanrahan, Colleen F. ^{[5
]}

Velen, Kavindhran ^{[6
]}

Chimoyi, Lucy ^{[7
]}

Charalambous, Salome ^{[7
,8
,9
]}

Chihota, Violet N. ^{[7
,8
,10
]}

机构：

[1] Johns Hopkins Univ, Dept Pediat, Baltimore, MD 21287 USA

[2] KNCV TB Fdn, Dept TB Eliminat & Hlth Syst Innovat, NL-2516 The Hague, Netherlands

[3] Univ Amsterdam, Amsterdam Inst Global Hlth & Dev, Med Ctr, NL-1105 Amsterdam, Netherlands

[4] Stellenbosch Univ, Fac Med & Hlth Sci, Desmond Tutu TB Ctr, Dept Paediat & Child Hlth, ZA-7500 Cape Town, South Africa

[5] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21287 USA

[6] Univ Sydney, Fac Med & Hlth, Cent Clin Sch, 90-92 Parramatta Rd, Sydney, NSW 2006, Australia

[7] Aurum Inst, ZA-2000 Johannesburg, South Africa

[8] Univ Witwatersrand, Sch Publ Hlth, ZA-2000 Johannesburg, South Africa

[9] Yale Sch Publ Hlth, Div Epidemiol Microbial Dis, New Haven, CT 06510 USA

[10] Vanderbilt Univ, Sch Med, Dept Med, Div Infect Dis, Nashville, TN 37240 USA

来源：

PATHOGENS | 2022年 / 11卷 / 11期

基金：

美国国家卫生研究院;

关键词：

TB infection; household contacts; TB preventive treatment; PULMONARY TUBERCULOSIS; WEEKLY RIFAPENTINE; COST-EFFECTIVENESS; CHILD CONTACTS; INFECTION; THERAPY; HIV; TRANSMISSION; BIOMARKER; ADULTS;

D O I：

10.3390/pathogens11111258

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

People who live in the household of someone with infectious pulmonary tuberculosis are at a high risk of tuberculosis infection and subsequent progression to tuberculosis disease. These individuals are prioritized for contact investigation and tuberculosis preventive treatment (TPT). The treatment of TB infection is critical to prevent the progression of infection to disease and is prioritized in household contacts. Despite the availability of TPT, uptake in household contacts is poor. Multiple barriers prevent the optimal implementation of these policies. This manuscript lays out potential next steps for closing the policy-to-implementation gap in household contacts of all ages.

引用

页数：13

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