Multiple independent introductions of Plasmodium falciparum in South America

被引：82

作者：

Yalcindag, Erhan ^{[1
]}

Elguero, Eric ^{[1
]}

Arnathau, Celine ^{[1
]}

Durand, Patrick ^{[1
]}

Akiana, Jean ^{[2
]}

Anderson, Timothy J. ^{[3
]}

Aubouy, Agnes ^{[4
]}

Balloux, Francois ^{[5
]}

Besnard, Patrick ^{[6
]}

Bogreau, Herve ^{[7
,8
]}

Carnevale, Pierre

D'Alessandro, Umberto ^{[9
]}

Fontenille, Didier ^{[1
]}

Gamboa, Dionicia ^{[10
]}

Jombart, Thibaut ^{[5
]}

Le Mire, Jacques

Leroy, Eric ^{[1
,11
]}

Maestre, Amanda ^{[12
]}

Mayxay, Mayfong ^{[13
]}

Menard, Didier ^{[14
]}

Musset, Lise ^{[15
]}

Newton, Paul N. ^{[13
]}

Nkoghe, Dieudonne ^{[11
]}

Noya, Oscar ^{[16
,17
]}

Ollomo, Benjamin ^{[11
]}

Rogier, Christophe ^{[7
,8
]}

Veron, Vincent ^{[18
]}

Wide, Albina ^{[16
,17
]}

Zakeri, Sedigheh ^{[19
]}

Carme, Bernard ^{[18
]}

Legrand, Eric

Chevillon, Christine ^{[1
]}

Ayala, Francisco J. ^{[20
]}

Renaud, Francois ^{[1
]}

Prugnolle, Franck ^{[1
]}

机构：

[1] Univ Montpellier 2, Univ Montpellier 1, Lab Malad Infect & Vecteurs, CNRS,Inst Rech Dev,Unite Mixte Rech 5290 224, F-34394 Montpellier 5, France

[2] Lab Natl Sante Publ, Dept Med Prevent & Essais Clin, Serv Epidemiol Mol & Parasitaire, Kinshasa 1, DEM REP CONGO

[3] Texas Biomed Res Inst, Dept Genet, San Antonio, TX 78245 USA

[4] Univ Toulouse 3, Inst Rech Dev, UMR 152, F-31062 Toulouse, France

[5] Univ London Imperial Coll Sci Technol & Med, Fac Med, Med Res Council Ctr Outbreak Anal & Modelling, Dept Infect Dis Epidemiol, London W2 1PG, England

[6] Soc Natl Met Sonamet, Malaria Control Program, Lobito, Angola

[7] French Army, Inst Biomed Res, Marseille 07, France

[8] Unite Mixte Rech 6236, Unite Rech Malad Infect & Trop Emergentes, Marseille 07, France

[9] Inst Trop Med, Dept Parasitol, B-2000 Antwerp, Belgium

[10] Univ Peruana Cayetano Heredia, Inst Med Trop Alexander von Humboldt, Lima 100, Peru

[11] Univ Mediterranee, Inst Rech Dev, Ctr Int Rech Med, Unite Emergence Pathol Virales,UMR 190, Franceville, Gabon

[12] Univ Antioquia, Fac Med, Grp Salud & Comunidad, Medellin, Colombia

[13] Wellcome Trust Mahosot Hosp Oxford Trop Med Res C, Microbiol Lab, Mahosot Hosp, Viangchan, Laos

[14] Pasteur Inst Cambodia, Mol Epidemiol Unit, Phnom Penh 12152, Cambodia

[15] Inst Pasteur, Parasitol Unit, Cayenne 97306, French Guiana

[16] Cent Univ Venezuela, Inst Trop Med, Caracas 2101, Venezuela

[17] Cent Univ Venezuela, Minist Poder Popular Salud, Ctr Estudios Malaria, Inst Altos Estudios Salud Dr Arnoldo Gabaldon, Caracas 2101, Venezuela

[18] Cayenne Gen Hosp, Ctr Invest Clin Epidemiol Clin Antilles, Cayenne 97306, French Guiana

[19] Pasteur Inst Iran, Biotechnol Res Ctr, Malaria & Vector Res Grp, Tehran 13164, Iran

[20] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92697 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 02期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

malaria origin; New World; human migrations; genetic diversity; MICROSATELLITE MARKERS; MALARIA; ORIGIN;

D O I：

10.1073/pnas.1119058109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence-archeological and genetic-suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade.

引用

页码：511 / 516

页数：6

共 34 条

[1] Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum [J].