The developing immune system - from foetus to toddler

被引：187
作者：
Ygberg, Sofia [1 ]
Nilsson, Anna [1 ]
机构：
[1] Karolinska Inst, Inst Woman & Child Hlth, Unit Clin Pediat, Stockholm, Sweden
来源：
ACTA PAEDIATRICA | 2012年 / 101卷 / 02期
关键词：
Immunology; Infant development; Infectious diseases; BIRTH-WEIGHT INFANTS; LATE-ONSET BACTERIAL; C-REACTIVE PROTEIN; CORD-BLOOD; DIAGNOSTIC MARKER; REFERENCE VALUES; INNATE IMMUNITY; T-CELLS; PROCALCITONIN; RESPONSES;
D O I：
10.1111/j.1651-2227.2011.02494.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
During foetal development, neonatal period and childhood, the immune system is constantly maturing. In the foetus, infection responsiveness is low and associates with spontaneous abortion. During the neonatal period, the infection response shifts towards a more pro-inflammatory response. The immune system of the newborn acquires adaptive features as a result of exposure to microbes. Conclusion: The development of the human immune system is a continuous process where both accelerated and retarded development is deleterious.
引用
收藏
页码：120 / 127
页数：8
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