Epithelial-Mesenchymal Plasticity in Tumor Immune Evasion

被引：30
作者：
Mullins, Riley D. Z. [1 ,2 ]
Pal, Ananya [1 ,2 ]
Barrett, Thomas F. [1 ,2 ]
Neal, Molly E. Heft [2 ]
Puram, Sidharth V. [1 ,2 ,3 ]
机构：
[1] Washington Univ, Dept Genet, Sch Med, St Louis, MO USA
[2] Washington Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, St Louis, MO USA
[3] Washington Univ, Otolaryngol Head & Neck Surg, Sch Med, 4515 McKinley Ave, St Louis, MO 63110 USA
来源：
CANCER RESEARCH | 2022年 / 82卷 / 13期
关键词：
CANCER STEM-CELLS; MHC CLASS-I; NF-KAPPA-B; E-CADHERIN; GROWTH-FACTOR; MIR-200; FAMILY; TRANSITION; EMT; CARCINOMA; METASTASIS;
D O I：
10.1158/0008-5472.CAN-21-4370
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epithelial-mesenchymal transition (EMT) is a fundamental process that occurs during embryogenesis and tissue repair. How-ever, EMT can be hijacked by malignant cells, where it may promote immune evasion and metastasis. Classically considered a dichoto-mous transition, EMT in cancer has recently been considered a plastic process whereby malignant cells display and interconvert among hybrid epithelial/mesenchymal (E/M) states. Epithelial- mesenchymal plasticity (EMP) and associated hybrid E/M states are divergent from classical EMT, with unique immunomodulatory effects. Here, we review recent insights into the EMP-immune cross -talk, highlighting possible mechanisms of immune evasion con-ferred by hybrid E/M states and roles of immune cells in EMP.
引用
收藏
页码：2329 / 2343
页数：15
相关论文
共 184 条
[111]   The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling [J].
Nappo, G. ;
Handle, F. ;
Santer, F. R. ;
McNeill, R. V. ;
Seed, R. I. ;
Collins, A. T. ;
Morrone, G. ;
Culig, Z. ;
Maitland, N. J. ;
Erb, H. H. H. .
ONCOGENESIS, 2017, 6 :e342-e342
[112]   Clinical Evolution of Epithelial-Mesenchymal Transition in Human Carcinomas [J].
Navas, Tony ;
Kinders, Robert J. ;
Lawrence, Scott M. ;
Ferry-Galow, Katherine, V ;
Borgel, Suzanne ;
Hollingshead, Melinda G. ;
Srivastava, Apurva K. ;
Alcoser, Sergio Y. ;
Makhlouf, Hala R. ;
Chuaqui, Rodrigo ;
Wilsker, Deborah F. ;
Konate, Mariam M. ;
Miller, Sarah B. ;
Voth, Andrea Regier ;
Chen, Li ;
Vilimas, Tomas ;
Subramanian, Jyothi ;
Rubinstein, Lawrence ;
Kummar, Shivaani ;
Chen, Alice P. ;
Bottaro, Donald P. ;
Doroshow, James H. ;
Parchment, Ralph E. .
CANCER RESEARCH, 2020, 80 (02) :304-318
[113]   The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200 [J].
Noman, Muhammad Zaeem ;
Janji, Bassam ;
Abdou, Abderemane ;
Hasmim, Meriem ;
Terry, Stephane ;
Tan, Tuan Zea ;
Mami-Chouaib, Fathia ;
Thiery, Jean Paul ;
Chouaib, Salem .
ONCOIMMUNOLOGY, 2017, 6 (01)
[114]   Inhibition of NF-kappa B pathway leads to deregulation of epithelial-mesenchymal transition and neural invasion in pancreatic cancer [J].
Nomura, Alice ;
Majumder, Kaustav ;
Giri, Bhuwan ;
Dauer, Patricia ;
Dudeja, Vikas ;
Roy, Sabita ;
Banerjee, Sulagna ;
Saluja, Ashok K. .
LABORATORY INVESTIGATION, 2016, 96 (12) :1268-1278
[115]   Cancer immunoediting and resistance to T cell-based immunotherapy [J].
O'Donnell, Jake S. ;
Teng, Michele W. L. ;
Smyth, Mark J. .
NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (03) :151-167
[116]   Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1 [J].
Ocana, Oscar H. ;
Corcoles, Rebeca ;
Fabra, Angels ;
Moreno-Bueno, Gema ;
Acloque, Herve ;
Vega, Sonia ;
Barrallo-Gimeno, Alejandro ;
Cano, Amparo ;
Angela Nieto, M. .
CANCER CELL, 2012, 22 (06) :709-724
[117]  
Oki E, 2017, J CLIN ONCOL, V35, p15s
[118]   Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade [J].
Ouzounova, Maria ;
Lee, Eunmi ;
Piranlioglu, Raziye ;
El Andaloussi, Abdeljabar ;
Kolhe, Ravindra ;
Demirci, Mehmet F. ;
Marasco, Daniela ;
Asm, Iskander ;
Chadli, Ahmed ;
Hassan, Khaled A. ;
Thangaraju, Muthusamy ;
Zhou, Gang ;
Arbab, Ali S. ;
Cowell, John K. ;
Korkaya, Hasan .
NATURE COMMUNICATIONS, 2017, 8
[119]   Partial EMT in head and neck cancer biology: a spectrum instead of a switch [J].
Pal, Ananya ;
Barrett, Thomas F. ;
Paolini, Rachel ;
Parikh, Anuraag ;
Puram, Sidharth V. .
ONCOGENE, 2021, 40 (32) :5049-5065
[120]   Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis [J].
Parikh, Anuraag S. ;
Puram, Sidharth V. ;
Faquin, William C. ;
Richmon, Jeremy D. ;
Emerick, Kevin S. ;
Deschler, Daniel G. ;
Varvares, Mark A. ;
Tirosh, Itay ;
Bernstein, Bradley E. ;
Lin, Derrick T. .
ORAL ONCOLOGY, 2019, 99
78910111213141516