Epithelial-Mesenchymal Plasticity in Tumor Immune Evasion

被引：30

作者：

Mullins, Riley D. Z. ^{[1
,2
]}

Pal, Ananya ^{[1
,2
]}

Barrett, Thomas F. ^{[1
,2
]}

Neal, Molly E. Heft ^{[2
]}

Puram, Sidharth V. ^{[1
,2
,3
]}

机构：

[1] Washington Univ, Dept Genet, Sch Med, St Louis, MO USA

[2] Washington Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, St Louis, MO USA

[3] Washington Univ, Otolaryngol Head & Neck Surg, Sch Med, 4515 McKinley Ave, St Louis, MO 63110 USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 13期

关键词：

CANCER STEM-CELLS; MHC CLASS-I; NF-KAPPA-B; E-CADHERIN; GROWTH-FACTOR; MIR-200; FAMILY; TRANSITION; EMT; CARCINOMA; METASTASIS;

D O I：

10.1158/0008-5472.CAN-21-4370

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial-mesenchymal transition (EMT) is a fundamental process that occurs during embryogenesis and tissue repair. How-ever, EMT can be hijacked by malignant cells, where it may promote immune evasion and metastasis. Classically considered a dichoto-mous transition, EMT in cancer has recently been considered a plastic process whereby malignant cells display and interconvert among hybrid epithelial/mesenchymal (E/M) states. Epithelial- mesenchymal plasticity (EMP) and associated hybrid E/M states are divergent from classical EMT, with unique immunomodulatory effects. Here, we review recent insights into the EMP-immune cross -talk, highlighting possible mechanisms of immune evasion con-ferred by hybrid E/M states and roles of immune cells in EMP.

引用

页码：2329 / 2343

页数：15

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