Neuroprotective mechanisms of hypothermia in brain ischaemia

被引：459
作者：
Yenari, Midori A. [1 ,2 ]
Han, Hyung Soo [3 ]
机构：
[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[2] San Francisco VA Med Ctr, San Francisco, CA 94121 USA
[3] Kyungpook Natl Univ, Sch Med, Dept Physiol, Taegu 700422, South Korea
来源：
NATURE REVIEWS NEUROSCIENCE | 2012年 / 13卷 / 04期
基金：
美国国家卫生研究院;
关键词：
FOCAL CEREBRAL-ISCHEMIA; FACTOR-KAPPA-B; ASPHYXIAL CARDIAC-ARREST; TO-MODERATE HYPOTHERMIA; SIGNAL-REGULATED KINASE; WHOLE-BODY HYPOTHERMIA; NECROSIS-FACTOR-ALPHA; RNA-BINDING PROTEIN; MILD HYPOTHERMIA; THERAPEUTIC HYPOTHERMIA;
D O I：
10.1038/nrn3174
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cooling can reduce primary injury and prevent secondary injury to the brain after insults in certain clinical settings and in animal models of brain insult. The mechanisms that underlie the protective effects of cooling - also known as therapeutic hypothermia are slowly beginning to be understood. Hypothermia influences multiple aspects of brain physiology in the acute, subacute and chronic stages of ischaemia. It affects pathways leading to excitotoxicity, apoptosis, inflammation and free radical production, as well as blood flow, metabolism and blood-brain barrier integrity. Hypothermia may also influence neurogenesis, gliogenesis and angiogenesis after injury. It is likely that no single factor can explain the neuroprotection provided by hypothermia, but understanding its myriad effects may shed light on important neuroprotective mechanisms.
引用
收藏
页码：267 / 278
页数：12
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