Fifteen-minute consultation: diagnosis and management of congenital CMV

被引：16

作者：

Shah, Tejshri ^{[1
]}

Luck, Suzanne ^{[2
,3
]}

Sharland, Mike ^{[3
]}

Kadambari, Seilesh ^{[3
]}

Heath, Paul ^{[3
]}

Lyall, Hermione ^{[1
]}

机构：

[1] Imperial Coll NHS Healthcare Trust, St Marys Hosp, Paediat Infect Dis, London, England

[2] Kingston Hosp NHS Fdn Trust, Dept Paediat, London, England

[3] St Georges Univ London, Paediat Infect Dis Res Grp, London, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION | 2016年 / 101卷 / 05期

关键词：

Infectious Diseases; Paediatric Practice; Virology; CYTOMEGALOVIRUS-INFECTION; VALGANCICLOVIR; GANCICLOVIR; THERAPY; HEARING;

D O I：

10.1136/archdischild-2015-309656

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Congenital cytomegalovirus (cCMV) infection can result in permanent neurological problems and is a potentially preventable cause of sensorineural hearing loss in the UK. There is an urgency to diagnose and assess cCMV as antiviral treatment and has only been shown to be effective if started in the first 4weeks of life. A recent randomised controlled trial of 6months of treatment using oral valganciclovir has shown modest benefit in preventing hearing deterioration and in improving some neurodevelopmental outcomes. Parents and clinicians need to make a timely and informed choice regarding antiviral treatment and ensure that relevant non-pharmaceutical interventions are considered. This paper brings together the current evidence regarding the diagnosis and treatment of cCMV, consensus from two paediatric infectious diseases centres and outlines research priorities.

引用

页码：232 / 235

页数：4

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