Fifteen-minute consultation: diagnosis and management of congenital CMV

被引：16

作者：

Shah, Tejshri ^{[1
]}

Luck, Suzanne ^{[2
,3
]}

Sharland, Mike ^{[3
]}

Kadambari, Seilesh ^{[3
]}

Heath, Paul ^{[3
]}

Lyall, Hermione ^{[1
]}

机构：

[1] Imperial Coll NHS Healthcare Trust, St Marys Hosp, Paediat Infect Dis, London, England

[2] Kingston Hosp NHS Fdn Trust, Dept Paediat, London, England

[3] St Georges Univ London, Paediat Infect Dis Res Grp, London, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION | 2016年 / 101卷 / 05期

关键词：

Infectious Diseases; Paediatric Practice; Virology; CYTOMEGALOVIRUS-INFECTION; VALGANCICLOVIR; GANCICLOVIR; THERAPY; HEARING;

D O I：

10.1136/archdischild-2015-309656

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Congenital cytomegalovirus (cCMV) infection can result in permanent neurological problems and is a potentially preventable cause of sensorineural hearing loss in the UK. There is an urgency to diagnose and assess cCMV as antiviral treatment and has only been shown to be effective if started in the first 4weeks of life. A recent randomised controlled trial of 6months of treatment using oral valganciclovir has shown modest benefit in preventing hearing deterioration and in improving some neurodevelopmental outcomes. Parents and clinicians need to make a timely and informed choice regarding antiviral treatment and ensure that relevant non-pharmaceutical interventions are considered. This paper brings together the current evidence regarding the diagnosis and treatment of cCMV, consensus from two paediatric infectious diseases centres and outlines research priorities.

引用

页码：232 / 235

页数：4

共 20 条

[1] Development of a novel single tube nested PCR for enhanced detection of cytomegalovirus DNA from dried blood spots [J].

Atkinson, C. ;

Emery, V. C. ;

Griffiths, P. D. .

JOURNAL OF VIROLOGICAL METHODS, 2014, 196 :40-44

[2] Congenital Cytomegalovirus Infection: Clinical Outcome [J].

Boppana, Suresh B. ;

Ross, Shannon A. ;

Fowler, Karen B. .

CLINICAL INFECTIOUS DISEASES, 2013, 57 :S178-S181

[3] Emergence of antiviral resistance during oral valganciclovir treatment of an infant with congenital cytomegalovirus (CMV) infection [J].

Choi, Yeon ;

Sharon, B. ;

Balfour, H. H., Jr. ;

Belani, K. ;

Pozos, T. C. ;

Schleiss, M. R. .

JOURNAL OF CLINICAL VIROLOGY, 2013, 57 (04) :356-360

[4] Ophthalmologic findings in children with congenital cytomegalovirus infection [J].

Coats, DK ;

Demmler, GJ ;

Paysse, EA ;

Du, LT ;

Libby, C .

JOURNAL OF AAPOS, 2000, 4 (02) :110-116

[5] Hearing Loss and Congenital CMV Infection: A Systematic Review [J].

Goderis, Julie ;

De Leenheer, Els ;

Smets, Koenraad ;

Van Hoecke, Helen ;

Keymeulen, Annelies ;

Dhooge, Ingeborg .

PEDIATRICS, 2014, 134 (05) :972-982

[6] Ganciclovir for the Treatment of Congenital Cytomegalovirus What are the Side Effects? [J].

Gwee, Amanda ;

Curtis, Nigel ;

Connell, Tom G. ;

Garland, Suzanne ;

Daley, Andrew J. .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2014, 33 (01) :115-115

[7] Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease [J].

Kimberlin, D. W. ;

Jester, P. M. ;

Sanchez, P. J. ;

Ahmed, A. ;

Arav-Boger, R. ;

Michaels, M. G. ;

Ashouri, N. ;

Englund, J. A. ;

Estrada, B. ;

Jacobs, R. F. ;

Romero, J. R. ;

Sood, S. K. ;

Whitworth, M. S. ;

Abzug, M. J. ;

Caserta, M. T. ;

Fowler, S. ;

Lujan-Zilbermann, J. ;

Storch, G. A. ;

DeBiasi, R. L. ;

Han, J. -Y. ;

Palmer, A. ;

Weiner, L. B. ;

Bocchini, J. A. ;

Dennehy, P. H. ;

Finn, A. ;

Griffiths, P. D. ;

Luck, S. ;

Gutierrez, K. ;

Halasa, N. ;

Homans, J. ;

Shane, A. L. ;

Sharland, M. ;

Simonsen, K. ;

Vanchiere, J. A. ;

Woods, C. R. ;

Sabo, D. L. ;

Aban, I. ;

Kuo, H. ;

James, S. H. ;

Prichard, M. N. ;

Griffin, J. ;

Giles, D. ;

Acosta, E. P. ;

Whitley, R. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (10) :933-943

[8] Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease [J].

Kimberlin, David W. ;

Acosta, Edward P. ;

Sanchez, Pablo J. ;

Sood, Sunil ;

Agrawal, Vish ;

Homans, James ;

Jacobs, Richard F. ;

Lang, David ;

Romero, Jose R. ;

Griffin, Jill ;

Cloud, Gretchen A. ;

Lakeman, Fred D. ;

Whitley, Richard J. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (06) :836-845

[9] Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system:: A randomized, controlled trial [J].

Kimberlin, DW ;

Lin, CY ;

Sánchez, PJ ;

Demmler, GJ ;

Dankner, W ;

Shelton, M ;

Jacobs, RF ;

Vaudry, W ;

Pass, RF ;

Kiell, JM ;

Soong, SJ ;

Whitley, RJ .

JOURNAL OF PEDIATRICS, 2003, 143 (01) :16-25

[10] Brain magnetic resonance findings in symptomatic congenital cytomegalovirus infection [J].

Manara, Renzo ;

Balao, Laura ;

Baracchini, Claudio ;

Drigo, Paola ;

D'Elia, Ruggiero ;

Ruga, Ezia Maria .

PEDIATRIC RADIOLOGY, 2011, 41 (08) :962-970

← 1 2 →